Open access · Peer reviewed · No APCs
Short communicationJournal of Young PharmacistsVol. 5 | Issue 2 | 2013 | pp. 70–72Open access
Sensitive polarographic electrochemical determination of clarithromycin in blood serum
- 1,
- 1*,
- 2
- 1 Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, MP 470003, INDIA.
- 2 Department of Pharmacognosy, Sagar Institute of Pharmaceutical Sciences, Sagar, MP 470228, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Ankit Jain
Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, MP 470003, INDIA.
Email: ankitjainsagar@gmail.com
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 18, 2013
- Received:
- May 15, 2013
- Accepted:
- Jul 10, 2013
How to cite
Jain, A., Jain, A., & Jain, A. (2013). Sensitive polarographic electrochemical determination of clarithromycin in blood serum. Journal of Young Pharmacists, 5(2), 70–72. https://doi.org/10.1016/j.jyp.2013.06.005
Abstract
Clarithromycin is an antibacterial widely used for the treatment of a myriad of infections. Various methods including HPLC have been reported for its drug plasma concentration but they are more complex. In this study, we developed an electrochemical method for estimation of clarithromycin in blood using differential pulse polarography (DPP) after oral administration of pure clarithromycin suspension. The differential pulse polarography of clarithromycin showed peak with peak potential Ep is -1460 mV SCE at pH 6.5(+-)0.1. The developed electrochemical method was standardized and validated for the determination of clarithromycin in blood serum of albino rats. PK analysis included Cmax, Tmax, AUC0-24, elimination rate constant (Kel) and t1/2. Cmax were found to be 1.34(+-)0.16 mg/ml and 1.99(+-)0.22 mg/ml for plain clarithromycin and suspension formulation, respectively. Effects of ammonium tartarate concentration and pH were also studied as specificity parameters. Developed electrochemical method was found to be simple, accurate method for to estimate blood-clarithromycin profile and can also be used similarly for various dosage forms.
Keywords
Subject
Article metadata
| Title | Sensitive polarographic electrochemical determination of clarithromycin in blood serum |
|---|---|
| Authors | Ashish Jain; Ankit Jain; Anki Jain |
| Affiliations | Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, MP 470003, INDIA.; Department of Pharmacognosy, Sagar Institute of Pharmaceutical Sciences, Sagar, MP 470228, INDIA. |
| Corresponding author | ankitjainsagar@gmail.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 5, Issue 2 (2013) |
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