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Research PaperJournal of Pharmacology and PharmacotherapeuticsVol. 11 | Issue 2 | 2020 | pp. 44–52Open access
Curcumin Improves the Behavior and Memory in Mice by Modulating the Core Circadian Genes and Their Associated Micro-RNAs
- 1,2,
- 2,
- 3,
- 3,
- 2*
- 1 Amity Institute of Neuropsychology and Neuroscience, Amity University, India.
- 2 Amity Institute of Pharmacy, Amity University, Noida, India.
- 3 School of Basic Sciences and Research, Department of Life Sciences, Sharda University, Greater Noida, Uttar Pradesh, India.
Published in Journal of Pharmacology and Pharmacotherapeutics
Correspondence: Maryam Sarwat
Amity Institute of Pharmacy, Amity University, Noida, India.
Email: msarwat@amity.edu
Copyright: © 2020 Manuscript Technomedia LLP. This is an open access article.
- Published:
- Oct 21, 2020
- Received:
- Jun 1, 2020
- Accepted:
- Sep 10, 2020
How to cite
Namgyal, D., Chandan, K., Ali, S., Mehta, R., & Sarwat, M. (2020). Curcumin Improves the Behavior and Memory in Mice by Modulating the Core Circadian Genes and Their Associated Micro-RNAs. Journal of Pharmacology and Pharmacotherapeutics, 11(2), 44–52. https://doi.org/10.4103/jpp.JPP_86_20
Abstract
Objective: To investigate the neuroprotective effects of curcumin in albino mice focusing on memory and behavior. Materials and Methods: Four groups of 7 mice each, different concentrations of curcumin were administered for 3 weeks in 3 groups and the remaining group was kept as control. The effect of curcumin on behavior and memory was studied using various tests. The expression of core circadian rhythm genes and micro RNAs were also studied. Results: Our results revealed that curcumin improves the mice’s behavior by regulating oxidative stress, hippocampal neurogenesis, and modulation of core circadian genes and their associated micro-RNA. Conclusion: This study shows that curcumin has a potential neuroprotective effect.
Keywords
Subject
Article metadata
| Title | Curcumin Improves the Behavior and Memory in Mice by Modulating the Core Circadian Genes and Their Associated Micro-RNAs |
|---|---|
| Authors | Dhondup Namgyal; Kumari Chandan; Sher Ali; Rachna Mehta; Maryam Sarwat |
| Affiliations | Amity Institute of Neuropsychology and Neuroscience, Amity University, India.; Amity Institute of Pharmacy, Amity University, Noida, India.; School of Basic Sciences and Research, Department of Life Sciences, Sharda University, Greater Noida, Uttar Pradesh, India. |
| Corresponding author | msarwat@amity.edu |
| Journal | Journal of Pharmacology and Pharmacotherapeutics |
| Volume / Issue | Vol. 11, Issue 2 (2020) |
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