Effects of glucocorticoids and tumor necrosis factor‑alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis

Serra, Raffaele; Grande, Raffaele; Buffone, Gianluca; Scarcello, Edoardo; Tripodi, Fabio; Rende, Pierandrea; Gallelli, Luca; Franciscis, Stefano de

doi:10.4103/0976-500X.136101

Research PaperJournal of Pharmacology and PharmacotherapeuticsVol. 5 | Issue 3 | 2014 | pp. 193–196Open access

Effects of glucocorticoids and tumor necrosis factor‑alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis

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¹ Departments of Medical and Surgical Science, Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.
² Department of Surgery, Unit of Vascular Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy.
³ Department of Pharmacological, Biological and Chemical Science, University of Parma, Parma, Italy.
⁴ Department of Health Science, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Correspondence: Raffaele Serra
Departments of Medical and Surgical Science, Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Published:: Jan 1, 2014
Received:: Jan 13, 2014
Accepted:: Feb 15, 2014
DOI:: 10.4103/0976-500X.136101

How to cite

Serra, R., Grande, R., Buffone, G., Scarcello, E., Tripodi, F., Rende, P., Gallelli, L., & Franciscis, S. D. (2014). Effects of glucocorticoids and tumor necrosis factor‑alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis. Journal of Pharmacology and Pharmacotherapeutics, 5(3), 193–196. https://doi.org/10.4103/0976-500X.136101

Abstract

Objective: To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor‑alpha inhibitors in patients with Takayasu arteritis (TA). Materials and Methods: In five patients with TA, the effects of the sequential treatment with prednisone for 5‑7 months and then with adalimumab (ADA) + methotrexate (MTX) or infliximab + MTX, or with ADA only, for 12 months on both clinical and laboratory findings were evaluated. Results: All treatments improved both symptoms and laboratory parameters without the development of side‑effects. Conclusions: It was hypothesized that MMP‑9 and neutrophil gelatinase‑associated lipocalin could be markers of the response to the treatments.

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Article metadata

Title	Effects of glucocorticoids and tumor necrosis factor‑alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis
Authors	Raffaele Serra; Raffaele Grande; Gianluca Buffone; Edoardo Scarcello; Fabio Tripodi; Pierandrea Rende; Luca Gallelli; Stefano de Franciscis
Affiliations	Departments of Medical and Surgical Science, Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.; Department of Surgery, Unit of Vascular Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy.; Department of Pharmacological, Biological and Chemical Science, University of Parma, Parma, Italy.; Department of Health Science, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Journal	Journal of Pharmacology and Pharmacotherapeutics
Volume / Issue	Vol. 5, Issue 3 (2014)