Original ArticlePharmacognosy ResearchVol. 13 | Issue 3 | 2021 | pp. 149–157Open access
Amentoflavone, New Hope against SARS-CoV-2: An Outlook through its Scientific Records and an in silico Study
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- 1 Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Dhaka, BANGLADESH.
- 2 Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, CHINA.
- 3 Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan, INDIA.
- 4 Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, BANGLADESH.
- 5 Faculty of Science, Liverpool John Moores University, Liverpool L33AF, England, UK.
- 6 Ethnobotany and Natural product Research Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar-11, Assam, INDIA.
- 7 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, England, UK.
- 8 Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran,, IRAN.
- 9 Department of Pharmacognosy and Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IRAN.
- 10 Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, CHILE.
- 11 Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IRAN.
- 12 Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, PORTUGAL.
- 13 Institute for Research and Innovation in Health (i3S), University of Porto, Porto,, PORTUGAL.
- 14 Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, PORTUGAL.
- 15 Graduate School of Natural and Applied Sciences, Gaziantep University, Gaziantep, TURKEY.
- 16 Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, ROMANIA.
- 17 Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, ROMANIA.
- 18 Facultad de Medicina, Universidad del Azuay, Cuenca, ECUADOR.
Published in Pharmacognosy Research
Correspondence: Javad Sharifi-Rad
Facultad de Medicina, Universidad del Azuay, Cuenca, ECUADOR.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran,, IRAN.
Email: javad.sharifirad@gmail.com
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 1, 2021
- Received:
- Mar 30, 2021
- Accepted:
- May 25, 2021
- DOI:
- 10.5530/pres.13.3.7
How to cite
Hossain, R., Islam, M. T., Ray, P., Jain, D., Saikat, A. S. M., Nahar, L., Talukdar, A. D., Sarker, S., Ayatollahi, S. A., Martorell, M., Kobarfard, F., Martins, N. C., Al-Khafaji, K., Docea, A. O., Calina, D., & Sharifi-Rad, J. (2021). Amentoflavone, New Hope against SARS-CoV-2: An Outlook through its Scientific Records and an in silico Study. Pharmacognosy Research, 13(3), 149–157. https://doi.org/10.5530/pres.13.3.7
Abstract
Background: The plant-derived bioflavonoid amentoflavone has many important biological activities, among them remarkable antiviral effects, even against severe acute respiratory syndrome Coronavirus (SARS-CoV). It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) with an IC50 value of 8.3 μM. TMPRSS-2 activity is now thought to be the only factor necessary for cell entry and viral pathogenesis). In comparison, 3CLPRO is needed for COVID-19 replication and maturation during its life cycle. Aim: This study aims to perform an in silico study on amentoflavone activity against structural and non-structural severe acute respiratory syndrome coronavirus (SARS-CoV)-2 3-chymotrypsin-like protease (3CLPRO) and human transmembrane protease serine 2 (TMPRSS-2) proteins. Materials and Methods: Molecular docking studies were carried out using compounds against 3CLPRO and TMPRSS-2 proteins through the Swiss model, Uniport, PROCHECK, Swiss PDB viewer, PyMol, PyRx, and Desmond (Schrödinger package) computerized software. Results: Amentoflavone showed strong interactions -9.5 and -7.4 kcal/mol with 3CLPRO and TMPRSS2 proteins, respectively. In any case, it had higher binding affinities than currently approved antiviral drugs, which are underutilized in coronavirus disease (COVID-19). Conclusion: Amentoflavone may be one of the potential leads (drug candidate) to fight human coronavirus, including SARS-CoV-2. Further in vivo studies are needed to support the findings of this study.
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Article metadata
| Title | Amentoflavone, New Hope against SARS-CoV-2: An Outlook through its Scientific Records and an in silico Study |
|---|---|
| Authors | Rajib Hossain; Muhammad Torequl Islam; Pranta Ray; Divya Jain; Abu Saim Mohammad Saikat; Lutfun Nahar; Anupam Das Talukdar; Satyajit Sarker; Seyed Abdulmajid Ayatollahi; Miquel Martorell; Farzad Kobarfard; Natália Cruz Martins; Khattab Al-Khafaji; Anca Oana Docea; Daniela Calina; Javad Sharifi-Rad |
| Affiliations | Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Dhaka, BANGLADESH.; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, CHINA.; Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan, INDIA.; Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, BANGLADESH.; Faculty of Science, Liverpool John Moores University, Liverpool L33AF, England, UK.; Ethnobotany and Natural product Research Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar-11, Assam, INDIA.; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, England, UK.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran,, IRAN.; Department of Pharmacognosy and Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IRAN.; Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, CHILE.; Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IRAN.; Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, PORTUGAL.; Institute for Research and Innovation in Health (i3S), University of Porto, Porto,, PORTUGAL.; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, PORTUGAL.; Graduate School of Natural and Applied Sciences, Gaziantep University, Gaziantep, TURKEY.; Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, ROMANIA.; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, ROMANIA.; Facultad de Medicina, Universidad del Azuay, Cuenca, ECUADOR. |
| Corresponding author | javad.sharifirad@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 13, Issue 3 (2021) |
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