Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy ResearchVol. 14 | Issue 3 | 2026 | pp. 304–309Open access
Anti-arthritic Potential of Aqueous and Ethanolic Extracts of Euphorbia helioscopia on Adjuvant-induced Arthritis in Rats
- 1,3,
- 2,3,
- 2,3*,
- 3,
- 2,3,
- 1
- 1 School of Life Sciences, Jaipur National University, Jaipur, Rajasthan, INDIA.
- 2 Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, INDIA.
- 3 PK-PD Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir, INDIA.
Published in Pharmacognosy Research
Correspondence: Syed Assim Haq
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, INDIA.; PK-PD Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir, INDIA.
Email: asimsyed37@gmail.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Aug 14, 2026
- Received:
- May 16, 2022
- Accepted:
- Jun 23, 2022
- DOI:
- 10.5530/pres.14.3.44
How to cite
Jan, I., Dogra, A., Haq, S. A., Dhiman, S., Singh, G., & Kumar, M. (2026). Anti-arthritic Potential of Aqueous and Ethanolic Extracts of Euphorbia helioscopia on Adjuvant-induced Arthritis in Rats. Pharmacognosy Research, 14(3), 304–309. https://doi.org/10.5530/pres.14.3.44
Abstract
Background: Euphorbia helioscopia is of the family Euphorbiaceae, owning various pharmacological properties like anti-inflammatory activity. Rheumatoid Arthritis (RA) is a chronic-autoimmune systemic disease that can be characterized by cartilage degradation, synovial hyperplasia, inflammation, and joint damage. Objectives: To assess the anti-arthritic activity of aqueous and ethanolic extracts of Euphorbia helioscopia. Materials and Methods: Adjuvant-induced arthritis (AIA) method was followed for the evaluation. Complete Freund’s adjuvant (CFA) was used to induce arthritis in female Wistar rats. Aqueous and ethanolic extracts (300, 150, and 75 mg/kg/day) of aerial parts of Euphorbia helioscopia were given orally to Wistar rats. Results: Both the extracts showed significant anti-arthritic activity in a dose-dependent manner. However, ethanolic extract (300mg/kg) of Euphorbia helioscopia showed potential anti-arthritic activity among the tested extracts. Conclusion: From the study, it can be concluded that Euphorbia helioscopia possesses marked anti-arthritic activity.
Keywords
Subject
Article metadata
| Title | Anti-arthritic Potential of Aqueous and Ethanolic Extracts of Euphorbia helioscopia on Adjuvant-induced Arthritis in Rats |
|---|---|
| Authors | Iram Jan; Ashish Dogra; Syed Assim Haq; Sumit Dhiman; Gurdarshan Singh; Mithilesh Kumar |
| Affiliations | School of Life Sciences, Jaipur National University, Jaipur, Rajasthan, INDIA.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, INDIA.; PK-PD Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir, INDIA. |
| Corresponding author | asimsyed37@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 14, Issue 3 (2026) |
Also in this issue
- Ayurveda: The Prominence of Herbal Medicine in Containment of COVID-19pp. 233–240
- Comparative Analysis of Antidermatophytic Potential of Cymbopogon citratus Essential Oil Stored in Different Temperature Condition for Two Years Articlespp. 241–245
- In silico Investigation on Phytoconstituents in Pamburus missionis S. for Antioxidant Activitypp. 246–250
- Clinical Assessment of Antimicrobial Effects of Brazilian Green Propolis on Chronic Woundspp. 251–255
- KRAS G12C as a Target of Naringenin for Inducing Cell Death in NCI-H23 Cellspp. 256–262
Readers Also Viewed
Effect of the Fractions of Coccinia grandis on Ethanol- Induced Cerebral Oxidative Stress in Rats
M. Umamaheswari, T. K. Chatterjee
Jan 1, 2009
Phytochemical Screening and Antioxidant Activity Evaluation of Selected Philippine Fruit Peels and Pulps
Mildred Dagcuta Pates, Angelo Mark Po Walag, Romeo M. Del Rosario
Aug 17, 2026
Impact of Artificial Intelligence Assisted Drug Therapy Optimization on Drug Related Problems Amongst Older Adult Patients: A Systematic Review
Jehath Syed, Christy Thomas, Bavneet Kaur
Oct 23, 2026