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Research ArticlePharmacognosy ResearchVol. 15 | Issue 4 | 2023 | pp. 813–818Open access
Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats
- 1,
- 2,
- 3,
- 4*
- 1 Department of Zoology, KVR Government College for Women (A), Cluster University, Kurnool, Andhra Pradesh, INDIA.
- 2 Department of Zoology, SCNR Government Degree College, Proddatur, Andhra Pradesh, INDIA.
- 3 Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, INDIA.
- 4 Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA.
Published in Pharmacognosy Research
Correspondence: Saddala Rajeswara Reddy
Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA.
Email: drsrr2017@gmail.com
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Oct 1, 2023
- Received:
- May 16, 2023
- Accepted:
- Aug 2, 2023
How to cite
Lavanya, T., Mohan, K. C., Reddy, K. S., & Reddy, S. R. (2023). Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats. Pharmacognosy Research, 15(4), 813–818. https://doi.org/10.5530/pres.15.4.086
Abstract
Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known as Pimpinella tirupatiensis (Pt). Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1. Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity. Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future.
Keywords
Subject
Article metadata
| Title | Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats |
|---|---|
| Authors | Thopireddy Lavanya; Kakarla Chandra Mohan; Kesireddy Sathyavelu Reddy; Saddala Rajeswara Reddy |
| Affiliations | Department of Zoology, KVR Government College for Women (A), Cluster University, Kurnool, Andhra Pradesh, INDIA.; Department of Zoology, SCNR Government Degree College, Proddatur, Andhra Pradesh, INDIA.; Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, INDIA.; Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA. |
| Corresponding author | drsrr2017@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 15, Issue 4 (2023) |
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