Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy ResearchVol. 17 | Issue 3 | 2025 | pp. 1020–1028Open access
Antioxidant, Stimulating Telomerase and Anxiolytic Activities of Polysaccharide Isolated from Sargentodoxa cuneata
- 1,2*,
- 1,
- 3,
- 1,2,
- 3,
- 4
- 1 School of Chinese Medicine, Bozhou University, Bozhou, CHINA.
- 2 Key Laboratory of Chinese Medicine Materials Research of Anhui Higher Education Institutes, Bozhou University, Bozhou, CHINA.
- 3 School of Pharmacy, Jiangsu University, Zhenjiang, CHINA.
- 4 Department of Neurology, The Affiliated Fourth People's Hospital of Jiangsu University, Zhenjiang, CHINA.
Published in Pharmacognosy Research
Correspondence: Jian Tang
School of Chinese Medicine, Bozhou University, Bozhou, CHINA.; Key Laboratory of Chinese Medicine Materials Research of Anhui Higher Education Institutes, Bozhou University, Bozhou, CHINA.
Email: jt.u@hotmail.com
Copyright: © 2025 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2025
- Received:
- Feb 28, 2025
- Accepted:
- Jun 3, 2025
How to cite
Tang, J., Zhou, P., Sun, H., Xu, X., Wen, C., & Xia, H. (2025). Antioxidant, Stimulating Telomerase and Anxiolytic Activities of Polysaccharide Isolated from Sargentodoxa cuneata. Pharmacognosy Research, 17(3), 1020–1028. https://doi.org/10.5530/pres.20252269
Abstract
Background
The classic anxiolytics have adverse effects in the treating anxiety disorders.
Aim
To identify the anxiolytic polysaccharide from Sargentodoxa cuneata.
Materials and Methods
The water-soluble Polysaccharide Fraction (PSC) was purified from S. cuneata, as well as its subfractions PSCA-1 and PSCB-1. The antioxidant effect of PSC against rotenone induced PC12 cell excitotoxicity, stimulating telomerase effect in HEK293T cell and anxiolytic effect on zebrafish were evaluated.
Results
The pretreatment of PC12 with PSC obviously increased cell survival and SOD level. PSC also down-regulated the LDH release, ROS level and cell apoptosis rate. PSC promoted the 293T cell proliferation, associated with the mechanism of stimulating telomerase. Additionally, PSC alleviated the anxiety level in zebrafish induced by mCPP.
Conclusion
These findings suggested that the PSC could possess the anxiolytic potential via antioxidant and telomerase activation.
Keywords
Subject
Article metadata
| Title | Antioxidant, Stimulating Telomerase and Anxiolytic Activities of Polysaccharide Isolated from Sargentodoxa cuneata |
|---|---|
| Authors | Jian Tang; Ping Zhou; Huifang Sun; Xiuquan Xu; Chongwei Wen; Haiping Xia |
| Affiliations | School of Chinese Medicine, Bozhou University, Bozhou, CHINA.; Key Laboratory of Chinese Medicine Materials Research of Anhui Higher Education Institutes, Bozhou University, Bozhou, CHINA.; School of Pharmacy, Jiangsu University, Zhenjiang, CHINA.; Department of Neurology, The Affiliated Fourth People's Hospital of Jiangsu University, Zhenjiang, CHINA. |
| Corresponding author | jt.u@hotmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 17, Issue 3 (2025) |
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