A Clinical Evaluation of the Safety and Efficacy of Melostacio Gold^TM (Pistachio Extract) to Manage Stress and Improve Sleep Quality: A Randomized, Double-Blind, Parallel, Placebo-Controlled Trial in Adults

Background and Objectives

Modern lifestyle nowadays leads adults towards chronic stress and poor sleep quality which impacts the health and well-being of an individual. While pharmacological interventions exist, their side effects have prompted interest in plant-based alternatives. Pistachio (Pistacia vera), known for its antioxidant and neuroprotective properties help in managing stress and improving sleep quality. This randomized, double-Blind, parallel, and placebo-Controlled trial was aimed at evaluating safety and efficacy of Melostacio Gold^TM (Pistachio extract) to manage stress and improve sleep quality in adults.

Materials and Methods

40 subjects were selected and were randomly divided into two equal groups. The study group participants received Melostacio Gold™ (100 mg) orally in the form of capsules for 28 days and various parameters such as sleep quality, levels of serum markers, and quality of life were measured at four key time points: Screening, Baseline, Day 14, and Day 28.

Results

The results revealed that AIS scores in the placebo group remained relatively stable while study group showed a significant reduction over time, from 16.95±1.96 at Visit 2 to 11.80±1.54 at Visit 4 (p<0.0001). The level of serum markers was also found to be decreasing from 35.81±4.54 at Visit 2 to 29.01±4.57 at Visit 4 (p<0.0001), indicating a marked decrease in stress levels.

Conclusion

In conclusion, Melostacio Gold™ (Pistachio extract) was found to be safe and effective in improving sleep quality, reducing stress, and enhancing overall well-being.