Investigations on the Anticancer Properties of Bark Extract of Couroupita guianensis against Breast Cancer

Background

One of the major causes of death in women is breast cancer worldwide. There are a lot of shortcomings in the proper diagnosis of breast cancer at early stages in the medical field. Unremitting research is going on for detecting breast cancer in the early stages as the possibility of a cure is bright.

Objectives

The present study on the C. guianensis plant aims to demonstrate the bioactive principles of methanol and aqueous bark extract and their potential cytotoxic properties.

Materials and Methods

The bark extracts of C. guianensis were subjected for sequential extraction using various solvents of increasing polarity for therapeutic analysis such as antioxidant, anti-inflammatory, antiangiogenesis and cytotoxicity.

Results

The bioactive compounds might have acted synergistically making these extracts potent and can be used as antioxidant and anti-inflammatory agents. Antiangiogenesis assay was performed by CAM assay showcasing antiangiogenesis and it showed the aqueous methanol extract of C. guianensis successfully demonstrated anticancer activity against MDA-MB-231 breast cancer Cell lines.

Conclusion

The present plant extracts may have potential bioactive compounds which can be utilized for therapeutic applications.