Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy ResearchVol. 2 | Issue 1 | 2010 | pp. 26–30Open access
Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats
- 1*,
- 1,
- 1
- 1 Herbal Drug Technology Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat - 390 001, India
Published in Pharmacognosy Research
Correspondence: Nirmal K. Bairwa
Herbal Drug Technology Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat - 390 001, India
Email: nirmalbairwa@gmail.com
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2010
- Received:
- Nov 18, 2009
- Accepted:
- Mar 13, 2010
How to cite
Bairwa, N. K., Sethiya, N. K., & Mishra, S. H. (2010). Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats. Pharmacognosy Research, 2(1), 26–30. https://doi.org/10.4103/0974-8490.60584
Abstract
The present study reports protective activity of ethyl acetate fraction of methanol extract of stem bark of Ceiba pentandra against paracetamol-induced liver damage in rats. The ethyl acetate fraction (400 mg/kg) was administered orally to the rats with hepatotoxicity induced by paracetamol (3 gm/kg). Silymarin (100 mg/kg) was used as positive control. High performance thin layer chromatography (HPTLC) fingerprinting of ethyl acetate fraction revealed presence of its major chemical constituents. A significant (P, 0.05) reduction in serum enzymes GOT (ALT), aspartate aminotransferase (AST), GPT alkaline phosphatase (ALP), total bilirubin content and histopathological screening in the rats treated gave indication that ethyl acetate fraction of methanolic extract of Ceiba pentandra possesses hepatoprotective potential against paracetamol-induced hepatotoxicity in rats.
Keywords
Subject
Article metadata
| Title | Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats |
|---|---|
| Authors | Nirmal K. Bairwa; Neeraj K. Sethiya; S. H. Mishra |
| Affiliations | Herbal Drug Technology Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat - 390 001, India |
| Corresponding author | nirmalbairwa@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 2, Issue 1 (2010) |
Also in this issue
- Natural product taking its own place!!!pp. 1–3
- Bioactivity of Syzygium jambos methanolic extracts: Antibacterial activity and toxicitypp. 4–9
- Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukinspp. 10–14
- Cardiac glycosides from shoot cultures of Cryptostegia grandiflorapp. 15–18
- The chemical composition and antimicrobial activity of the leaf oil of Cupressus lusitanica from Monteverde, Costa Ricapp. 19–21
Readers Also Viewed
Effect of the Fractions of Coccinia grandis on Ethanol- Induced Cerebral Oxidative Stress in Rats
M. Umamaheswari, T. K. Chatterjee
Jan 1, 2009
Phytochemical Screening and Antioxidant Activity Evaluation of Selected Philippine Fruit Peels and Pulps
Mildred Dagcuta Pates, Angelo Mark Po Walag, Romeo M. Del Rosario
Aug 17, 2026
Impact of Artificial Intelligence Assisted Drug Therapy Optimization on Drug Related Problems Amongst Older Adult Patients: A Systematic Review
Jehath Syed, Christy Thomas, Bavneet Kaur
Oct 23, 2026