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Original ArticlePharmacognosy ResearchVol. 2 | Issue 1 | 2010 | pp. 26–30Open access
Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats
- 1*,
- 1,
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- 1 Herbal Drug Technology Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat - 390 001, India
Published in Pharmacognosy Research
Correspondence: Nirmal K. Bairwa
Herbal Drug Technology Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat - 390 001, India
Email: nirmalbairwa@gmail.com
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2010
- Received:
- Nov 18, 2009
- Accepted:
- Mar 13, 2010
How to cite
Bairwa, N. K., Sethiya, N. K., & Mishra, S. H. (2010). Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats. Pharmacognosy Research, 2(1), 26–30. https://doi.org/10.4103/0974-8490.60584
Abstract
The present study reports protective activity of ethyl acetate fraction of methanol extract of stem bark of Ceiba pentandra against paracetamol-induced liver damage in rats. The ethyl acetate fraction (400 mg/kg) was administered orally to the rats with hepatotoxicity induced by paracetamol (3 gm/kg). Silymarin (100 mg/kg) was used as positive control. High performance thin layer chromatography (HPTLC) fingerprinting of ethyl acetate fraction revealed presence of its major chemical constituents. A significant (P, 0.05) reduction in serum enzymes GOT (ALT), aspartate aminotransferase (AST), GPT alkaline phosphatase (ALP), total bilirubin content and histopathological screening in the rats treated gave indication that ethyl acetate fraction of methanolic extract of Ceiba pentandra possesses hepatoprotective potential against paracetamol-induced hepatotoxicity in rats.
Keywords
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Article metadata
| Title | Protective effect of stem bark of Ceiba pentandra linn. against paracetamol-induced hepatotoxicity in rats |
|---|---|
| Authors | Nirmal K. Bairwa; Neeraj K. Sethiya; S. H. Mishra |
| Affiliations | Herbal Drug Technology Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat - 390 001, India |
| Corresponding author | nirmalbairwa@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 2, Issue 1 (2010) |
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