Cytotoxic essential oil from Annona sengalensis Pers. leaves

Ahmed, A. L.; Bassem, S. E. M.; Mohamed, Y. H.; Gamila, M. W.

doi:10.4103/0974-8490.69105

Original ArticlePharmacognosy ResearchVol. 2 | Issue 4 | 2010 | pp. 211–214Open access

Cytotoxic essential oil from Annona sengalensis Pers. leaves

¹^*,
²,
³,
²

¹ Department of Health Information Technology of Jeddah Community College, King Abdul-Aziz University, Al- Rehab, 80283 Jeddah, Kingdom of Saudi Arabia
² Department Pharmacognosy, National Research Centre Dokki, 12622 Giza, Egypt
³ Department Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Correspondence: A. L. Ahmed
Department of Health Information Technology of Jeddah Community College, King Abdul-Aziz University, Al- Rehab, 80283 Jeddah, Kingdom of Saudi Arabia
Email: ahmedabdellateff@yahoo.com

Published:: Jan 1, 2010
Received:: Jan 30, 2010
Accepted:: Sep 7, 2010
DOI:: 10.4103/0974-8490.69105

How to cite

Ahmed, A. L., Bassem, S. E. M., Mohamed, Y. H., & Gamila, M. W. (2010). Cytotoxic essential oil from Annona sengalensis Pers. leaves. Pharmacognosy Research, 2(4), 211–214. https://doi.org/10.4103/0974-8490.69105

Abstract

The cytotoxicity against brine shrimp of the essential oil obtained from the leaves of Annona senegalensis Pers. (Annonaceae) was studied. The confirmation of this toxicity has been done by using selected tumor cell lines (A549, HT29, MCF 7, RPMI, and U251). The results showed that the total oil and its fractions have showed mild to moderate cytotoxicity in brine shrimp lethality bioassay with LC50 = 27.3 μg/ml, and against some human tumor cell lines. The total oil and its fractions were analyzed by gas chromatography/mass spectroscopy (GC/MS). Seventy three compounds were identified.

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Article metadata

Title	Cytotoxic essential oil from Annona sengalensis Pers. leaves
Authors	A. L. Ahmed; S. E. M. Bassem; Y. H. Mohamed; M. W. Gamila
Affiliations	Department of Health Information Technology of Jeddah Community College, King Abdul-Aziz University, Al- Rehab, 80283 Jeddah, Kingdom of Saudi Arabia; Department Pharmacognosy, National Research Centre Dokki, 12622 Giza, Egypt; Department Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Corresponding author	ahmedabdellateff@yahoo.com
Journal	Pharmacognosy Research
Volume / Issue	Vol. 2, Issue 4 (2010)