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EditorialPharmacognosy ResearchVol. 3 | Issue 1 | 2011 | pp. 40–43Open access
Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves
- 1*,
- 1,
- 2,
- 1,
- 3
- 1 Phytochemistry and Pharmacology Laboratory, Department of Post Graduate Studies and Research in Biotechnology and Bioinformatics, School of Biological Sciences, Kuvempu University, Shankaraghatta - 577 451
- 2 Department of Post Graduate Studies and Research in Biotechnology, SDM College (Autonomous), Ujire - 574 240
- 3 Department of Pathology, Shivamogga Institution of Medical Sciences Shivamogga - 577 201, Karnataka, India
Published in Pharmacognosy Research
Correspondence: P. Suresh Babu
Phytochemistry and Pharmacology Laboratory, Department of Post Graduate Studies and Research in Biotechnology and Bioinformatics, School of Biological Sciences, Kuvempu University, Shankaraghatta - 577 451
Email: spbioinfo@yahoo.co.in
Copyright: © 2011 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2011
How to cite
Babu, P. S., Krishna, V., Maruthi, K. R., Shankarmurthy, K., & Babu, R. K. (2011). Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves. Pharmacognosy Research, 3(1), 40–43. https://doi.org/10.4103/0974-8490.79114
Abstract
Background
D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye diseases and have an aphrodisiac property. In present study, It was aimed to test the hepatoprotective activity of the plant.
Material and Methods
The methanolic extract of Dichrostachys cinerea (Mimoseae) leaves was subjected to evaluation of acute toxicity and hepatoprotective property, using albino mice and rats. The parameters for estimation of liver function, based on serum markers such as total bilirubin, total protein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase with histopathological profile of the liver tissue, were studied consequently.
Results
The methanolic extract did not show any mortality up to a dose of 3500 mg/kg body weight. The methanolic extract showed significant hepatoprotectivity. The histopathological profile of the drug-treated liver tissue demonstrated similar morphology as that of controls.
Conclusions
Methanolic extract of Dichrostachys cinerea was found to have significant hepatoprotective activity.
Keywords
Subject
Article metadata
| Title | Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves |
|---|---|
| Authors | P. Suresh Babu; V. Krishna; K. R. Maruthi; K. Shankarmurthy; Ramesh K. Babu |
| Affiliations | Phytochemistry and Pharmacology Laboratory, Department of Post Graduate Studies and Research in Biotechnology and Bioinformatics, School of Biological Sciences, Kuvempu University, Shankaraghatta - 577 451; Department of Post Graduate Studies and Research in Biotechnology, SDM College (Autonomous), Ujire - 574 240; Department of Pathology, Shivamogga Institution of Medical Sciences Shivamogga - 577 201, Karnataka, India |
| Corresponding author | spbioinfo@yahoo.co.in |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 3, Issue 1 (2011) |
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