Open access · Peer reviewed · No APCs
EditorialPharmacognosy ResearchVol. 3 | Issue 2 | 2011 | pp. 130–134Open access
Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of Solanum torvum Swartz (Solanaceae)
- 1*,
- 1,
- 1
- 1 Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kumasi, Ghana
Published in Pharmacognosy Research
Correspondence: George A. Koffuor
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kumasi, Ghana
Email: gkoffuor@yahoo.com
Copyright: © 2011 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2011
How to cite
Koffuor, G. A., Amoateng, P., & Andey, T. A. (2011). Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of Solanum torvum Swartz (Solanaceae). Pharmacognosy Research, 3(2), 130–134. https://doi.org/10.4103/0974-8490.81961
Abstract
Aim
The effect of Solanum torvum (Fam: Solanaceae) on delayed type hypersensitivity (DTH) response, hemagglutinating antibody (HA) titer, white blood cells (WBC), red blood cells (RBC) and hemoglobin concentration was investigated in Sprague-Dawley rats to establish immunomodulatory and erythropoietic activity.
Materials and Methods
Sheep red blood cells (SRBC)-immunized and challenged rats were treated with Solanum torvum extract, levamisole and dexamethasone. Phenylhydrazine (PHZ)-induced anemia in rats was treated with the extract.
Results
The aqueous Solanum torvum extract and levamisole significantly enhanced DTH response, increased HA titer and WBC count, while dexamethasone significantly decreased DTH response, did not increase HA titer, and did not enhance WBC profile. The extract and Feroglobin, the reference heamatinic, were able to reverse PHZ-induced anemia, and increase the RBCs and Hb concentration above baseline values within 24 days.
Conclusion
Solanum torvum extract showed a concentration- dependent immunostimulant and erythropoietic activity.
Keywords
Subject
Article metadata
| Title | Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of Solanum torvum Swartz (Solanaceae) |
|---|---|
| Authors | George A. Koffuor; Patrick Amoateng; Terrick A. Andey |
| Affiliations | Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kumasi, Ghana |
| Corresponding author | gkoffuor@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 3, Issue 2 (2011) |
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