Open access · Peer reviewed · No APCs
EditorialPharmacognosy ResearchVol. 5 | Issue 3 | 2013 | pp. 169–172Open access
Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis
- 1,
- 2*
- 1 Department of Pharmacy-Biology, University of Prishtina, Prishtina, Kosovo
- 2 Department of Biomedical Sciences, Centre for Biomedical Research, University of Dhaka, Bangladesh
Published in Pharmacognosy Research
Correspondence: Muhammad Feroz Hayat Khan
Department of Biomedical Sciences, Centre for Biomedical Research, University of Dhaka, Bangladesh
Email: m.fhayaht.khan@gmail.com
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2013
How to cite
Sopi, R. B., & Khan, M. F. H. (2013). Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis. Pharmacognosy Research, 5(3), 169–172. https://doi.org/10.4103/0974-8490.112422
Abstract
Background
Nyctanthes arbortristis has been used in traditional medicine for the treatment of asthma and cough.
Aim
In this study, bronchodilatory effect of ethanolic extract of the N. arbortristis was investigated under in vitro conditions. The concentration–response curve of the tracheal smooth muscle (TSM) to histamine was recorded in presence or absence of ethanolic extract and Nw-nitro-l-arginine methyl ester (L-NAME). Dose–response effect of ethanolic extract on pre-constricted tissues was investigated. The ethanolic extract inhibited the histamine-induced maximum contractile responses of TSM (P < 0.001). Ethanolic extract also cause dose-dependent relaxation of TSM. These effects were reversed by L-NAME. Phytochemical analysis showed the presence of typical plant constituents. These results suggest the possible use of extract of the leaves of N. arbortristis as a bronchodilator in therapeutic treatment of asthma.
Keywords
Subject
Article metadata
| Title | Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis |
|---|---|
| Authors | Ramadan B. Sopi; Muhammad Feroz Hayat Khan |
| Affiliations | Department of Pharmacy-Biology, University of Prishtina, Prishtina, Kosovo; Department of Biomedical Sciences, Centre for Biomedical Research, University of Dhaka, Bangladesh |
| Corresponding author | m.fhayaht.khan@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 5, Issue 3 (2013) |
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