Open access · Peer reviewed · No APCs
EditorialPharmacognosy ResearchVol. 5 | Issue 3 | 2013 | pp. 173–178Open access
Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents
- 1*,
- 2,
- 1,
- 3
- 1 Departments of Physiology, Faculty of Basic Medical Sciences, College of Medicine
- 2 Veterinary Pathology, Faculty of Veterinary Medicine
- 3 Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
Published in Pharmacognosy Research
Correspondence: Samuel Adetunji Onasanwo
Departments of Physiology, Faculty of Basic Medical Sciences, College of Medicine
Email: samphil2002@yahoo.com
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2013
How to cite
Onasanwo, S. A., Emikpe, B. O., Ajah, A. A., & Elufioye, T. O. (2013). Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents. Pharmacognosy Research, 5(3), 173–178. https://doi.org/10.4103/0974-8490.112423
Abstract
Background
This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats.
Materials and Methods
Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats.
Results
The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P £ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group.
Conclusion
The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.
Keywords
Subject
Article metadata
| Title | Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents |
|---|---|
| Authors | Samuel Adetunji Onasanwo; Benjamin Obukowho Emikpe; Austin Azubuike Ajah; Taiwo Olayemi Elufioye |
| Affiliations | Departments of Physiology, Faculty of Basic Medical Sciences, College of Medicine; Veterinary Pathology, Faculty of Veterinary Medicine; Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria |
| Corresponding author | samphil2002@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 5, Issue 3 (2013) |
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