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ORIGINAL ARTICLEPharmacognosy ResearchVol. 6 | Issue 1 | 2014 | pp. 73–86Open access
Effect of Momordica dioica fruit extract on antioxidant status in liver, kidney, pancreas, and serum of diabetic rats
- 1,
- 2*
- 1 Departments of Zoology
- 2 Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India
Published in Pharmacognosy Research
Correspondence: Rambir Singh
Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India
Email: sehrawat_r@yahoo.com
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2014
How to cite
Sharma, P., & Singh, R. (2014). Effect of Momordica dioica fruit extract on antioxidant status in liver, kidney, pancreas, and serum of diabetic rats. Pharmacognosy Research, 6(1), 73–86. https://doi.org/10.4103/0974-8490.122922
Abstract
Background
Fruits, leaves, and tuberous roots of Momordica dioica are used as a folk remedy for diabetes mellitus (DM) in India. The aqueous extract of Momordica dioica fruit possesses very good anti-diabetic activity and is having high margin of safety.
Objectives
The aim of the present study was to investigate the antioxidative effect of Momordica dioica fruits in alloxan-induced diabetic Wistar rats.
Materials and Methods
Effect of aqueous extract of Momordica dioica (AEMD) on thiobarbituric acid reactive substances (TBARS), hydroperoxide (HP), non-enzymatic and enzymatic antioxidants in liver, kidney, pancreas, and serum was evaluated in diabetic rats after 21 days treatment.
Results
Increase in the levels of TBARS, HP and decrease in the levels of non-enzymatic antioxidants and activity of enzymatic antioxidants was observed in liver, kidney, pancreas, and serum of diabetic rats when compared with normal healthy rats. TBARS and HP levels were reduced while non-enzymatic and enzymatic antioxidant enzymes activity was increased in AEMD and glibenclamide-treated rats. Furthermore, histological examination of liver, kidney, and pancreas of diabetic rats showed degenerative changes. AEMD treatment for 21 days rejuvenated liver, kidney, and pancreas histoarchitecture.
Conclusion
In conclusion, the present results showed the protective role of AEMD on liver, kidney, and pancreas in severe diabetic rats justifying support for its anti-diabetic use in folk medicine.
Keywords
Subject
Article metadata
| Title | Effect of Momordica dioica fruit extract on antioxidant status in liver, kidney, pancreas, and serum of diabetic rats |
|---|---|
| Authors | Poonam Sharma; Rambir Singh |
| Affiliations | Departments of Zoology; Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India |
| Corresponding author | sehrawat_r@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 6, Issue 1 (2014) |
Also in this issue
- The hypoglycemic effect of the aqueous extract of the fruits of Balanites aegypticea in Alloxan-induced diabetic ratspp. 1–5
- Comparative study to evaluate the anti-viral efficacy of Glycyrrhiza glabra extract and ribavirin against the Newcastle disease viruspp. 6–11
- Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participantspp. 12–18
- Protection of CCl4-Induced Liver and Kidney Damage by Phenolic Compounds in Leaf Extracts of Cnestis ferruginea (de Candolle)pp. 19–28
- Evaluation of Phyllanthus emblica extract on cold pressor induced cardiovascular changes in healthy human subjectspp. 29–35
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