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Short CommunicationPharmacognosy ResearchVol. 9 | Issue 3 | 2017 | pp. 301–303Open access
Ex vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum
- 1*,
- 1,
- 1
- 1 Department of Pharmacology, Southern Institute of Medical Sciences, Guntur, Andhra Pradesh, INDIA.
Published in Pharmacognosy Research
Correspondence: Kannan Vadivel
Department of Pharmacology, Southern Institute of Medical Sciences, Guntur, Andhra Pradesh, INDIA.
Email: vadivelshiva@yahoo.co.in
Copyright: © 2017 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2017
- DOI:
- 10.4103/pr.pr_99_16
How to cite
Vadivel, K., Kumar, G. S., & Babu, S. M. (2017). Ex vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum. Pharmacognosy Research, 9(3), 301–303. https://doi.org/10.4103/pr.pr_99_16
Abstract
Objective: The present study has been undertaken with the main objective of evaluating the aqueous extract of flowers of Muntingia calabura for antispasmodic activity on isolated rabbit’s jejunum. Materials and Methods: The study was carried out on isolated rabbit’s jejunum preparations. The aqueous extract of flowers of M. calabura was applied in different doses by cumulative manner without washing the tissue. Spontaneous contractions abolished by the extract were recorded. Results: In isolated rabbit’s jejunum preparation, the flower extract of M. calabura inhibited the spontaneous contractions in a concentration‑dependent manner with IC100 value of 36 ± 3.02 μg/mL, which is potent than the standard drug verapamil with IC100 value of 40 ± 1.02 μg/mL on the rabbit’s jejunum. Conclusion: The aqueous extract of flowers of M. calabura exhibits significant dose‑dependent relaxations of spontaneous contractions in isolated rabbit’s jejunum preparations.
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Article metadata
| Title | Ex vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum |
|---|---|
| Authors | Kannan Vadivel; Gollapudi Sandeep Kumar; Sitty Manohar Babu |
| Affiliations | Department of Pharmacology, Southern Institute of Medical Sciences, Guntur, Andhra Pradesh, INDIA. |
| Corresponding author | vadivelshiva@yahoo.co.in |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 9, Issue 3 (2017) |
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