Open access · Peer reviewed · No APCs
Short CommunicationPharmacognosy ResearchVol. 9 | Issue 3 | 2017 | pp. 301–303Open access
Ex vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum
- 1*,
- 1,
- 1
- 1 Department of Pharmacology, Southern Institute of Medical Sciences, Guntur, Andhra Pradesh, INDIA.
Published in Pharmacognosy Research
Correspondence: Kannan Vadivel
Department of Pharmacology, Southern Institute of Medical Sciences, Guntur, Andhra Pradesh, INDIA.
Email: vadivelshiva@yahoo.co.in
Copyright: © 2017 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2017
- DOI:
- 10.4103/pr.pr_99_16
How to cite
Vadivel, K., Kumar, G. S., & Babu, S. M. (2017). Ex vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum. Pharmacognosy Research, 9(3), 301–303. https://doi.org/10.4103/pr.pr_99_16
Abstract
Objective: The present study has been undertaken with the main objective of evaluating the aqueous extract of flowers of Muntingia calabura for antispasmodic activity on isolated rabbit’s jejunum. Materials and Methods: The study was carried out on isolated rabbit’s jejunum preparations. The aqueous extract of flowers of M. calabura was applied in different doses by cumulative manner without washing the tissue. Spontaneous contractions abolished by the extract were recorded. Results: In isolated rabbit’s jejunum preparation, the flower extract of M. calabura inhibited the spontaneous contractions in a concentration‑dependent manner with IC100 value of 36 ± 3.02 μg/mL, which is potent than the standard drug verapamil with IC100 value of 40 ± 1.02 μg/mL on the rabbit’s jejunum. Conclusion: The aqueous extract of flowers of M. calabura exhibits significant dose‑dependent relaxations of spontaneous contractions in isolated rabbit’s jejunum preparations.
Keywords
Subject
Article metadata
| Title | Ex vivo Antispasmodic Activity of Aqueous Extract of Flowers of Muntingia calabura Linn. on Excised Rabbit’s Jejunum |
|---|---|
| Authors | Kannan Vadivel; Gollapudi Sandeep Kumar; Sitty Manohar Babu |
| Affiliations | Department of Pharmacology, Southern Institute of Medical Sciences, Guntur, Andhra Pradesh, INDIA. |
| Corresponding author | vadivelshiva@yahoo.co.in |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 9, Issue 3 (2017) |
Also in this issue
- Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae) Sensitizes THP‑1 Cells to Radiation‑induced Cell Deathpp. 221–229
- High Performance Thin layer Chromatography: Densitometry Method for Determination of Rubraxanthone in the Stem Bark Extract of Garcinia cowa Roxbpp. 230–233
- Investigation of Effect of 1,8‑cineole on Antimicrobial Activity of Chlorhexidine Gluconatepp. 234–237
- Antioxidant and Antiproliferative Activity of Asparagopsis taxiformispp. 238–246
- Ameliorative Effect of Curcumin on Olanzapine-induced Obesity in Sprague-Dawley Rats pp. 247–252
Readers Also Viewed
Effect of the Fractions of Coccinia grandis on Ethanol- Induced Cerebral Oxidative Stress in Rats
M. Umamaheswari, T. K. Chatterjee
Jan 1, 2009
Phytochemical Screening and Antioxidant Activity Evaluation of Selected Philippine Fruit Peels and Pulps
Mildred Dagcuta Pates, Angelo Mark Po Walag, Romeo M. Del Rosario
Aug 17, 2026
Impact of Artificial Intelligence Assisted Drug Therapy Optimization on Drug Related Problems Amongst Older Adult Patients: A Systematic Review
Jehath Syed, Christy Thomas, Bavneet Kaur
Oct 23, 2026