Open access · Peer reviewed · No APCs
ORIGINAL ARTICLEPharmacognosy MagazineVol. 11 | Issue 44s1 | 2015 | pp. 251–257Open access
Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin‑induced diabetes mellitus in experimental animals
- 1*,
- 1,
- 1,
- 1,
- 2
- 1 Department of Clinical Pharmacy, College of Pharmacy, Northern Borders University, Rafha, Kingdom of Saudi Arabia.
- 2 King Fahad Medical Research center, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Published in Pharmacognosy Magazine
Correspondence: Sibghatullah Muhammad Ali Sangi
Department of Clinical Pharmacy, College of Pharmacy, Northern Borders University, Rafha, Kingdom of Saudi Arabia.
Email: doctor_sangi@yahoo.com
Copyright: © 2015 Manuscript Technomedia. This is an open access article.
- Published:
- Sep 24, 2015
- Received:
- Apr 23, 2015
How to cite
Sangi, S. M. A., Sulaiman, M. I., El‑wahab, M. F. A., Ahmedani, E. I., & Ali, S. S. (2015). Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin‑induced diabetes mellitus in experimental animals. Pharmacognosy Magazine, 11(44s1), 251–257. https://doi.org/10.4103/0973-1296.166017
Abstract
Background: Diabetes mellitus is one of the most important diseases related with endocrines. Its main manifestation includes abnormal metabolism of carbohydrates and lipids and inappropriate hyperglycemia that is caused by absolute or relative insulin deficiency. It affects humankind worldwide. Objectives: Our research was aimed to observe antihyperglycemic activity of thymoquinone and oleuropein. Materials and Methods: In this study, rats were divided into six groups, 6 rats in each. Diabetes was inducted by streptozotocin (STZ). The level of fasting blood glucose was determined for each rats during the experiment, doses of thymoquinone and oleuropein (3 mg/kg and 5 mg/kg) for both, were injected intraperitoneal. Pancreatic tissues were investigated to compare β‑cells in diabetic and treated rats. Result and Conclusion: It was found that thymoquinone and oleuropein significantly decrease serum Glucose levels in STZ induced diabetic rats.
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Article metadata
| Title | Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin‑induced diabetes mellitus in experimental animals |
|---|---|
| Authors | Sibghatullah Muhammad Ali Sangi; Mansour Ibrahim Sulaiman; Mohammed Fawzy Abd El‑wahab; Elsamoual Ibrahim Ahmedani; Soad Shaker Ali |
| Affiliations | Department of Clinical Pharmacy, College of Pharmacy, Northern Borders University, Rafha, Kingdom of Saudi Arabia.; King Fahad Medical Research center, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. |
| Corresponding author | doctor_sangi@yahoo.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 11, Issue 44s1 (2015) |
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