Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 15 | Issue 64s | 2019 | pp. S359–S365Open access
Catha edulis‑induced Skeletal Muscle Toxicity in Experimental Rats via Regulation of Rhabdomyolysis Biomarkers
- 2*,
- 2,
- 3,4,
- 2,
- 5,
- 2,6,
- 1 Medical Research Centre, Jazan University.
- 2 Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
- 3 Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Jazan University.
- 4 Department of Biology, Faculty of Science, Jazan University.
- 5 Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University.
- 6 Substance Abuse Research Center, Jazan University, Jazan, Saudi Arabia.
Published in Pharmacognosy Magazine
Correspondence: Syam Mohan
Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
Email: syammohanm@yahoo.com
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Aug 26, 2019
- Received:
- Apr 1, 2019
- Accepted:
- Mar 15, 2019
- DOI:
- 10.4103/pm.pm_142_19
How to cite
Mohan, S., Shaheen, E., El‑Amir, Y. O., Khadashi, H. A., Ncibi, S. S., Farasani, A., & Abdelwahab, S. I. (2019). Catha edulis‑induced Skeletal Muscle Toxicity in Experimental Rats via Regulation of Rhabdomyolysis Biomarkers. Pharmacognosy Magazine, 15(64s), S359–S365. https://doi.org/10.4103/pm.pm_142_19
Abstract
Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Crotalaria pallida</em> Aiton (MECP) leaves. Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-induced granuloma models. The analgesic activity was assessed using acetic acid-induced writhing and hot plate methods in mice. Results: MECP (200 and 400 mg/kg) showed significant (P < 0.01) anti-inflammatory activity in both acute and chronic models. In the analgesic models, MECP exhibited significant (P < 0.01) reduction in the number of writhes and increased the reaction time in the hot plate test. Conclusion: The results suggest that <em>C. pallida</em> possesses significant anti-inflammatory and analgesic activities, which may be attributed to the presence of phytochemicals like flavonoids and alkaloids.
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Article metadata
| Title | Catha edulis‑induced Skeletal Muscle Toxicity in Experimental Rats via Regulation of Rhabdomyolysis Biomarkers |
|---|---|
| Authors | Syam Mohan; Emad Shaheen; Yasmin O. El‑Amir; Hussein A. Khadashi; Saida S. Ncibi; Abdullah Farasani; Siddig Ibrahim Abdelwahab |
| Affiliations | Medical Research Centre, Jazan University.; Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.; Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Jazan University.; Department of Biology, Faculty of Science, Jazan University.; Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University.; Substance Abuse Research Center, Jazan University, Jazan, Saudi Arabia. |
| Corresponding author | syammohanm@yahoo.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 15, Issue 64s (2019) |
Also in this issue
- The Antioxidant Paradoxpp. S173–S175
- Pterodon emarginatus Hydroalcoholic Extract: Antioxidant and Photoprotective Activities, Noncytotoxic Effect, and Perspective of Obtaining Formulations with Photochemoprotective Activitypp. S176–S182
- Optimization of Ultrasound‑Assisted Extraction of L‑Ascorbic Acid from Adansonia digitata (Linn.) and Evaluation of its Antityrosinase Activitypp. S183–S188
- Anti-inflammatory and Analgesic Activities of Crotalaria pallida Aitonpp. S189–S196
- Anti-adipogenic Effect of Terminalia chebula Fruit Aqueous Extract in 3T3-L1 Preadipocytespp. S197–S204
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