Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 16 | Issue 69 | 2020 | pp. 317–320Open access
Phytochemical Analysis, Antipropulsive and Antilymphoma Activities of Leaves Extract of Annona cherimola Miller
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- 1 Unidad de Investigación Médica en Farmacología, Unidad Médica de Alta Especialidad, Hospital de Especialidades‑2° Piso CORSE Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cd México, 1Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, San Agustin Tlaxiaca, Pachuca, Hidalgo, Mexico.
- 2 Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luís y Díaz Mirón, Mexico.
- 3 Unidad de Investigación Médica en Genética Humana Unidad Médica de Alta Especialidad, Hospital de Pediatría. Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cd Mexico.
Published in Pharmacognosy Magazine
Correspondence: Fernando Calzada
Unidad de Investigación Médica en Farmacología, Unidad Médica de Alta Especialidad, Hospital de Especialidades‑2° Piso CORSE Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cd México, 1Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, San Agustin Tlaxiaca, Pachuca, Hidalgo, Mexico.
Email: fercalber10@gmail.com
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 15, 2020
- Received:
- Oct 18, 2019
- Accepted:
- Dec 16, 2019
- DOI:
- 10.4103/pm.pm_462_19
How to cite
Calzada, F., Valdés, M., Merlin, V. I., Velázquez, C., Barbosa, E., Chávez‑Soto, M., Pina‑Jiménez, E., Ordoñez‑Razo, R. M., & García‑Hernández, N. (2020). Phytochemical Analysis, Antipropulsive and Antilymphoma Activities of Leaves Extract of Annona cherimola Miller. Pharmacognosy Magazine, 16(69), 317–320. https://doi.org/10.4103/pm.pm_462_19
Abstract
Objectives: The present work reports the identification of flavonol glycosides present in the ethanol crude extract using high‑performance liquid chromatography with diode array detection (HPLC‑DAD). Materials and Methods: The identification of flavonoids was made by comparing their retention times and ultraviolet spectra with those standards. The crude extract, dichloromethane, and aqueous residual (AR) fractions were tested for their antipropulsive and antilymphoma activities. Results: The results revealed high levels of three flavonoid glycosides (rutin, nicotiflorin, and narcissin), especially rutin (24.5 mg/g of extract). The antipropulsive and antilymphoma activities of the leaf extract and subsequent fractions showed that the ethanol extract of the leaves of A. cherimola is cursive and AR fraction exhibited the best biological effects in both assays. Conclusion: The HPLC‑DAD method used in this work enables the determination of rutin as a major flavonol glycoside of the leaves of A. cherimola. In addition, it can be suggested that rutin may play an important role in the biological properties of A. cherimola.
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Article metadata
| Title | Phytochemical Analysis, Antipropulsive and Antilymphoma Activities of Leaves Extract of Annona cherimola Miller |
|---|---|
| Authors | Fernando Calzada; Miguel Valdés; Verenice Itzel Merlin; Claudia Velázquez; Elizabeth Barbosa; Marco Chávez‑Soto; Emmanuel Pina‑Jiménez; Rosa Maria Ordoñez‑Razo; Normand García‑Hernández |
| Affiliations | Unidad de Investigación Médica en Farmacología, Unidad Médica de Alta Especialidad, Hospital de Especialidades‑2° Piso CORSE Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cd México, 1Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, San Agustin Tlaxiaca, Pachuca, Hidalgo, Mexico.; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luís y Díaz Mirón, Mexico.; Unidad de Investigación Médica en Genética Humana Unidad Médica de Alta Especialidad, Hospital de Pediatría. Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cd Mexico. |
| Corresponding author | fercalber10@gmail.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 69 (2020) |
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