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Original ArticlePharmacognosy MagazineVol. 16 | Issue 70s | 2020 | pp. S284–S289Open access
Amelioration of Doxorubicin‑Induced Cardiotoxicity by Oral Lyophilized Dunaliella salina Supplement in a Female Wistar Rat Model with Active Estrous Cycle and Surgical Menopause
- 1,
- 1*
- 1 Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Published in Pharmacognosy Magazine
Correspondence: Kodiveri Muthukaliannan Gothandam
Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Email: gothandam@gmail.com
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Aug 28, 2020
- Received:
- Feb 29, 2020
- Accepted:
- Apr 21, 2020
- DOI:
- 10.4103/pm.pm_52_20
How to cite
Gomathinayagam, S., & Gothandam, K. M. (2020). Amelioration of Doxorubicin‑Induced Cardiotoxicity by Oral Lyophilized Dunaliella salina Supplement in a Female Wistar Rat Model with Active Estrous Cycle and Surgical Menopause. Pharmacognosy Magazine, 16(70s), S284–S289. https://doi.org/10.4103/pm.pm_52_20
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> L. is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present study was aimed to evaluate the anti-inflammatory and antioxidant activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) stem. Materials and Methods: The anti-inflammatory activity was evaluated using the carrageenan-induced rat paw edema model. The antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, and total phenolic content (TPC) determination. Results: MECQ showed significant anti-inflammatory activity in a dose-dependent manner. In the antioxidant assays, MECQ exhibited potent radical scavenging activity and high phenolic content. Conclusion: The results suggest that <em>Cissus quadrangularis</em> possesses significant anti-inflammatory and antioxidant properties, which may contribute to its traditional medicinal uses.
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Article metadata
| Title | Amelioration of Doxorubicin‑Induced Cardiotoxicity by Oral Lyophilized Dunaliella salina Supplement in a Female Wistar Rat Model with Active Estrous Cycle and Surgical Menopause |
|---|---|
| Authors | Sankaranarayanan Gomathinayagam; Kodiveri Muthukaliannan Gothandam |
| Affiliations | Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India. |
| Corresponding author | gothandam@gmail.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 70s (2020) |
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- Polyphenol‑Enriched Fraction and the Compounds Isolated from Garcinia indica Fruits Ameliorate Obesity through Suppression of Digestive Enzymes and Oxidative Stresspp. S236–S245
- New Phytopharmaceutical Formulations: Development and Characterization of Tablets Containing the Aerial Part of the Plant Pulverized and the Soft Extract from Bidens pilosa Standardized on Rutinpp. S246–S254
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