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Original ArticlePharmacognosy MagazineVol. 16 | Issue 72 | 2021 | pp. 797–802Open access
Anti-inflammatory and antioxidant activities of Cissus quadrangularis stem extract
- 1,
- 1,
- 2,
- 3,
- 1*
- 1 Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh, India.
- 2 Department of Mathematics, National Institute of Technology, Raipur, Chhattisgarh, India.
- 3 Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh, India.
Published in Pharmacognosy Magazine
Correspondence: Vishnu Agarwal
Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh, India.
Email: vishnua@mnnit.ac.in
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Feb 16, 2021
- Received:
- Aug 3, 2020
- Accepted:
- Dec 1, 2020
- DOI:
- 10.4103/pm.pm_315_20
How to cite
Kalia, M., Singh, D., Sharma, D., Narvi, S. S., & Agarwal, V. (2021). Anti-inflammatory and antioxidant activities of Cissus quadrangularis stem extract. Pharmacognosy Magazine, 16(72), 797–802. https://doi.org/10.4103/pm.pm_315_20
Abstract
Aim: This study was carried out with the objective to attenuate quorum sensing (QS)‑controlled virulence factors in P. aeruginosa and its biofilm. Methods: In the present study, acetone and hexane extracts of S. alexandriana mill were tested at sub‑minimum inhibitory concentration concentrations for their anti‑QS activity using bioreporter strain the Chromobacterium violaceum CV026. The effect of S. alexandriana Mill on different virulence phenotypes such as pyocyanin and protease production was investigated. Finally, the effect of the extract on P. aeruginosa, biofilm formation was also determined using the spectrophotometry‑based method and microscopic analysis. Results: The extracts were tested for their activities against QS‑controlled virulence factors of P. aeruginosa at 600 µg/ml and 800 µg/ml acetone and hexane extract concentration, respectively. Results showed that both the extracts have an inhibitory effect on different virulence factors of P. aeruginosa, including pyocyanin, protease production, and biofilm formation, without affecting the growth. The P. aeruginosa biofilm was found to be decreased by 75% and 62% in acetone and hexane extract presence. Conclusion: The results revealed that both acetone and hexane extracts showed anti‑biofilm and anti‑QS activity. It depicted the potential of S. alexandriana Mill against P. aeruginosa infection, its biofilm, and QS.
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Article metadata
| Title | Anti-inflammatory and antioxidant activities of Cissus quadrangularis stem extract |
|---|---|
| Authors | Manmohit Kalia; Devendra Singh; Deepmala Sharma; Shahid Suhail Narvi; Vishnu Agarwal |
| Affiliations | Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh, India.; Department of Mathematics, National Institute of Technology, Raipur, Chhattisgarh, India.; Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh, India. |
| Corresponding author | vishnua@mnnit.ac.in |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 72 (2021) |
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