Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 17 | Issue 74 | 2021 | pp. 275–281Open access
Resveratrol Exerts Anti‑Inflammatory Effect in Lipopolysaccharide‑Induced Lung Inflammation via Downregulation of Antioxidant and Inflammatory Mediators
- 1*,
- 1*,
- 1,
- 2,
- 3,
- 4*
- 1 Department of Pulmonary and Critical Care Medcine, Chengdu Institute of Respiratory Health,The Third People’s Hospital of Chengdu, Chengdu, Sichuan Province, China.
- 2 Department of Intensive Medicine, The People’s Hospital of Guangrao, Dongying, Shandong Province, China.
- 3 Department of Emergency, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
- 4 Department of ICU, Affiliated Hospital of Weifang Medical College, WeiFang, Shandong Province, China.
Published in Pharmacognosy Magazine
Correspondence: Xinxin Liang
Department of Pulmonary and Critical Care Medcine, Chengdu Institute of Respiratory Health,The Third People’s Hospital of Chengdu, Chengdu, Sichuan Province, China.
Email: chixiaoming2019@sina.com
Correspondence: Jian Shen
Department of Pulmonary and Critical Care Medcine, Chengdu Institute of Respiratory Health,The Third People’s Hospital of Chengdu, Chengdu, Sichuan Province, China.
Email: chixiaoming2019@sina.com
Correspondence: Xiaoming Chi
Department of ICU, Affiliated Hospital of Weifang Medical College, WeiFang, Shandong Province, China.
Email: chixiaoming2019@sina.com
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Jul 12, 2021
- Received:
- Mar 21, 2020
- Accepted:
- Mar 12, 2021
- DOI:
- 10.4103/pm.pm_41_20
How to cite
Liang, X., Shen, J., Duan, X., Zhou, R., Liu, P., & Chi, X. (2021). Resveratrol Exerts Anti‑Inflammatory Effect in Lipopolysaccharide‑Induced Lung Inflammation via Downregulation of Antioxidant and Inflammatory Mediators. Pharmacognosy Magazine, 17(74), 275–281. https://doi.org/10.4103/pm.pm_41_20
Abstract
Objectives: In this study, the chemoprotective effect of resveratrol and its of mechanism of action against the Lipopolysaccharide (LPS)-induced lung inflammation was investigated. Materials and Methods: In this in vitro study, we performed experiments using RAW 264.7 cells. LPS was used to induce inflammation in the lungs of Swiss Wistar rats that were randomly divided into different groups. The rats were treated with resveratrol in a dose-dependent manner. The lung tissue and dry/wet weight of lung tissue was estimated. The antioxidant activity and anti-inflammatory parameters were also estimated. Results: According to results, resveratrol significantly reduced the secretion of pro-inflammatory cytokines including interleukin (IL)-1β, IL-4, IL-6, tumor necrosis factor-α (TNF-α), IL-18, IL-10, and antioxidant parameters viz., glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD), respectively. Resveratrol significantly (P<0.001) reduced the weight of lung tissue and dry/wet of lung tissue at dose-dependent manner. Conclusion: In summary, resveratrol plays the role of a chemo-protective agent against the LPS-induced lung inflammation via anti-inflammatory and antioxidant mechanism.
Keywords
Subject
Article metadata
| Title | Resveratrol Exerts Anti‑Inflammatory Effect in Lipopolysaccharide‑Induced Lung Inflammation via Downregulation of Antioxidant and Inflammatory Mediators |
|---|---|
| Authors | Xinxin Liang; Jian Shen; Xueming Duan; Rongbing Zhou; Peng Liu; Xiaoming Chi |
| Affiliations | Department of Pulmonary and Critical Care Medcine, Chengdu Institute of Respiratory Health,The Third People’s Hospital of Chengdu, Chengdu, Sichuan Province, China.; Department of Intensive Medicine, The People’s Hospital of Guangrao, Dongying, Shandong Province, China.; Department of Emergency, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of ICU, Affiliated Hospital of Weifang Medical College, WeiFang, Shandong Province, China. |
| Corresponding author | chixiaoming2019@sina.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 17, Issue 74 (2021) |
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