Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 18 | Issue 79 | 2022 | pp. 738–745Open access
Fracture Healing in SD Rats’ Bioactivities of Cucumber Seed Polysaccharides
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- 1 Department of Chinese Medicine Processing, Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China.
- 2 Department of Chinese Medicine Processing, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
- 3 Zhongshan Institude for Drug Discovery, Zhongke Zhongshan Institute of Drug Innovation, Zhongshan, China.
Published in Pharmacognosy Magazine
Correspondence: Haixue Kuang
Department of Chinese Medicine Processing, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Email: hxkuang@hljucm.net
Correspondence: Qiuhong Wang
Department of Chinese Medicine Processing, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Zhongshan Institude for Drug Discovery, Zhongke Zhongshan Institute of Drug Innovation, Zhongshan, China.
Email: qhwang668@sina.com
Copyright: © 2022 Manuscript Technomedia. This is an open access article.
- Published:
- Sep 19, 2022
- Received:
- Jan 12, 2022
- Accepted:
- Jul 19, 2022
- DOI:
- 10.4103/pm.pm_14_22
How to cite
Zhang, Z., Zeng, Y., Peng, D., Xing, N., Bai, H., Li, Y., Cui, N., Su, H., Qiao, T., Shi, C., Kuang, H., & Wang, Q. (2022). Fracture Healing in SD Rats’ Bioactivities of Cucumber Seed Polysaccharides. Pharmacognosy Magazine, 18(79), 738–745. https://doi.org/10.4103/pm.pm_14_22
Abstract
Background: We investigated the composition and structure of intracellular polysaccharides in cucumber seeds (CSs) and their effect on Sprague-Dawley (SD) rats and potential activity for fracture healing. Materials and Methods: Polysaccharides are its main water‑soluble active ingredient. The SD rat tibia fracture model was established by surgical method, and the healing effect of cucumber seed polysaccharides (CSPs) on SD rat tibia fracture was preliminarily explored. Through histopathological observation, determination of rat serum indicators alkaline phosphatase (AKP), acid phosphatase (ACP), BGP, X‑ray imaging observation, and micro‑Computed Tomography (CT) imaging observation at different periods. Results and Conclusion: The results showed that CSP enhanced the activity of osteoblasts, increased the metabolic rate of osteoclasts, increased the secretion of AKP, BGP, and ACP, shortened the fracture healing time of SD rats and effectively promoted the healing of tibial fractures in SD rats.
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Article metadata
| Title | Fracture Healing in SD Rats’ Bioactivities of Cucumber Seed Polysaccharides |
|---|---|
| Authors | Zhihong Zhang; Yuanning Zeng; Donghui Peng; Na Xing; Haodong Bai; Yuxin Li; Na Cui; Huilin Su; Tingting Qiao; Congjing Shi; Haixue Kuang; Qiuhong Wang |
| Affiliations | Department of Chinese Medicine Processing, Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China.; Department of Chinese Medicine Processing, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Zhongshan Institude for Drug Discovery, Zhongke Zhongshan Institute of Drug Innovation, Zhongshan, China. |
| Corresponding author | hxkuang@hljucm.net |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 18, Issue 79 (2022) |
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