Protective Effect of Mangiferin an active Phytochemical and Cardiotonic from Mangifera Indica Linn on Isoproterenol induced myocardial infarcted Rats- An Electrocardiographic, Electrophoretic and Biochemical Evidences

The protective role of mangiferin an active phyto-chemical extracted from Mangifera indica Linn was tested on isoproterenol (ISPH) administered experimental myocardial infarction in rats and was confirmed by ECG study in rat heart, electrophoresis analysis of serum protein, serum A/G ratio, biochemical studies such as heart tissue protein, glycogen, nucleic acids and blood glucose. Subcutaneous injection of ISPH (20 mg / 100g body weight in 0.1 ml saline) to rats for 2 consecutive days caused myocardial damage and was confirmed by elevation of ST segments in rat heart ECG pattern, reduction in serum electrophoresis protein bands and serum A/G ratio, increase in heart tissue protein and nucleic acids, increase in blood glucose and decrease in heart tissue glycogen. Pretreatment with mangiferin (10 mg / 100 g body weight in 0.2 ml of dimethyl sulphoxide) for 28 days through intraperitonial injection in ISPH administered rats protected the above-mentioned parameters from alterations as compared with myocardial infarcted rats. This confirmed the myocardial protective role of mangiferin on ISPH-induced myocardial infarction in rats.