Inhibition of nitric oxide and interferon-γ production by iridoids and triterpenes from the roots of Himatanthus sucuuba

Souza, Marinete S.; Cordeiro, Milade dos S.; Rosas, Elaine C.; Henriques, Maria das Graças O. M.; Siani, Antonio C.

Research ArticlePharmacognosy MagazineVol. 2 | Issue 8 | 2006 | pp. 216–217Open access

Inhibition of nitric oxide and interferon-γ production by iridoids and triterpenes from the roots of Himatanthus sucuuba

¹,
¹,
²,
²,
²^*

¹ Departamento de Química Orgânica, Instituto de Química, Fundação Universidade do Amazonas, Manaus, AM, Brazil.
² Laboratório de Química de Produtos Naturais e Farmacologia Aplicada, Far-Manguinhos, Fundação Oswaldo Cruz, Rua Sizenando Nabuco 100, 21041-250, Rio de Janeiro, RJ, Brazil.

Correspondence: Antonio C. Siani
Laboratório de Química de Produtos Naturais e Farmacologia Aplicada, Far-Manguinhos, Fundação Oswaldo Cruz, Rua Sizenando Nabuco 100, 21041-250, Rio de Janeiro, RJ, Brazil.
Email: siani@far.fiocruz.br

Published:: Jan 1, 2006

How to cite

Souza, M. S., Cordeiro, M. D. S., Rosas, E. C., Henriques, M. D. G. O. M., & Siani, A. C. (2006). Inhibition of nitric oxide and interferon-γ production by iridoids and triterpenes from the roots of Himatanthus sucuuba. Pharmacognosy Magazine, 2(8), 216–217.

Abstract

The iridoids β-dihydroplumericin (1), plumericin and isoplumericin were isolated from the roots of Himatanthus sucuuba, along with lupeol acetate and cinnamate. The isolated compounds and three different crude extracts from the roots exhibited in vitro immunoregulatory activity in the nitric oxide and interferon-γ inhibition assays, when tested below the cytotoxic concentrations.

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Article metadata

Title	Inhibition of nitric oxide and interferon-γ production by iridoids and triterpenes from the roots of Himatanthus sucuuba
Authors	Marinete S. Souza; Milade dos S. Cordeiro; Elaine C. Rosas; Maria das Graças O. M. Henriques; Antonio C. Siani
Affiliations	Departamento de Química Orgânica, Instituto de Química, Fundação Universidade do Amazonas, Manaus, AM, Brazil.; Laboratório de Química de Produtos Naturais e Farmacologia Aplicada, Far-Manguinhos, Fundação Oswaldo Cruz, Rua Sizenando Nabuco 100, 21041-250, Rio de Janeiro, RJ, Brazil.
Corresponding author	siani@far.fiocruz.br
Journal	Pharmacognosy Magazine
Volume / Issue	Vol. 2, Issue 8 (2006)