Open access · Peer reviewed · No APCs
Research ArticlePharmacognosy MagazineVol. 4 | Issue 15 | 2008 | pp. 182–183Open access
Preventive and curative effects of Vedic Guard against anti- tubercular drugs induced hepatic damage in rats
- 1*,
- 1,
- 1
- 1 Dept. of Pharmacology, Al Ameen College of Pharmacy, Lalbagh road, Bangalore – 560027, India.
- 2 Visveswarapura Institute of Pharmaceutical Sciences, Banashankari 2 nd stage, Bangalore – 560070, India.
Published in Pharmacognosy Magazine
Correspondence: Rema Razdan
Dept. of Pharmacology, Al Ameen College of Pharmacy, Lalbagh road, Bangalore – 560027, India.
Email: rrazdan2002@yahoo.com
Copyright: © 2008 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2008
How to cite
Razdan, R., Imranulla, I., & M.J., A. D. (2008). Preventive and curative effects of Vedic Guard against anti- tubercular drugs induced hepatic damage in rats. Pharmacognosy Magazine, 4(15), 182–183.
Abstract
Vedic Guard, a polyherbal formulation in Ayurveda has been investigated for its possible or claimed hepatoprotective potential. Anti-tuberculosis drugs caused an increase in the activity of serum diagnostic markers ASAT, ALAT, ALP and total bilirubin, and a decrease in total plasma protein. Hepatic liver peroxidation was enhanced and free radical scavenging enzyme levels of superoxide dismuase (SOD), catalase (CAT) and glutathione (GSH) were reduced. Administration of Vedic Guard simultaneously with anti-TB drugs for 45 days prevented the alterations induced by the anti-TB drugs in the markers of liver function test and markers of oxidative stress. Treatment with Vedic Guard for 20 days post 45 days administration of anti TB drugs reversed the damage caused by the toxicant. Improvement in the histoarchitecture of liver also supported the biochemical studies. In conclusion, Vedic Guard exhibited preventive and curative effects on the hepatotoxicity induced by anti-TB drugs in rats.
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Article metadata
| Title | Preventive and curative effects of Vedic Guard against anti- tubercular drugs induced hepatic damage in rats |
|---|---|
| Authors | Rema Razdan; Imranulla Imranulla; Amar Dev M.J. |
| Affiliations | Dept. of Pharmacology, Al Ameen College of Pharmacy, Lalbagh road, Bangalore – 560027, India.; Visveswarapura Institute of Pharmaceutical Sciences, Banashankari 2 nd stage, Bangalore – 560070, India. |
| Corresponding author | rrazdan2002@yahoo.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 4, Issue 15 (2008) |
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