Rapid determination of paeoniflorin

Correspondence: Viroj Wiwanitkit
performance liquid chromatography in pharmaceutical analyses. Bosn J Basic Med Sci 2004;4:5-9. Uncovering negative results: Introducing an open access journal “Journal of Pharmaceutical Negative Results” Sir, “Once you replace negative thoughts with positive ones, you'll start having positive results.” —Willie Nelson Drug discovery nowadays is a highly innovative process by which new drugs are discovered and/or designed. It L E T T E R S T O E D I T O R P H C O G M A G . is expected that in the year 2010, at least 50% of all new approved drugs will come from the biopharmaceutical sector. The discovery and validation process is mostly carried out by new innovative and medium-sized companies. But, despite advances in technology and greater understanding of biological systems, drug discovery is still a lengthy process. Specialized drug discovery companies need an ideal business climate, that is, political, economic, and social conditions, to be able to cope with the entrepreneurial risks of drug development. Global pharmaceutical industry is at the crossroads. On one side, market demand for novel and better medicines is getting redefined and growing due to demographic, economic, and epidemiologic trends, but at the same time, pharmaceutical companies are finding it difficult to survive because they are unable to innovate and discover new molecules. The pipeline of the new drug molecules is drying fast due to poor R&D productivity, high failure rate, and generic competition.[1] Scientific research proceeds with an infinite variety in the availability of data, the maturity of conceptions, and the mix of conviction and uncertainty. Often a major discovery is the culmination of a process with numerous blunders, wrong turns, false hypotheses, missed opportunities, persistent hard work, lucky breaks, rational arguments, insightful conjectures, and accumulation of knowledge over decades. But none of the failures are being reported or published in the journals and other resources. This part is always ignored because of the publishing style of most of the journals in the pharmaceutical field. Welcome to the Journal of Pharmaceutical Negative Results (PNR). We are proud to introduce you to a new home for negative results focused on all aspects of Pharmacy. Journal of Pharmaceutical Negative Results[2] represents the first open access source for research concerning negative results and will be a valuable resource for researchers all over the world, both to those who are already experts and also to those entering the field. Journal of Pharmaceutical Negative Results is a peer-reviewed journal developed to publish original, innovative, and novel research articles with negative results. This peerreviewed scientific journal publishes theoretic and empiric papers that report negative findings and research failures in the pharmaceutical field. Submissions should have a negative focus, which means the output of research yielded in negative results is given more preference. All theoretic and methodologic perspectives are welcomed. We also encourage the submission of short papers/.
Email: wviroj@yahoo.com

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