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Original ArticlePharmacognosy MagazineVol. 7 | Issue 26 | 2011 | pp. 133–140Open access
Protective effects on myelosuppression mice treated by three different classic Chinese medicine formulae
- 1*,
- 2*,
- 2,
- 3,
- 2,
- 4,
- 2*
- 1 Department of Internal Medicine, Xinzheng Chinese Medical Hospital, Zhengzhou, People's Republic of China.
- 2 Department of Traditional Chinese Medicine, Medical College, Jinan University, Guangzhou, People's Republic of China.
- 3 Department of Traditional Chinese Medicine, School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.
- 4 Department of Laboratory, Guangzhou Red Cross Hospital, Guangzhou, People's Republic of, China.
Published in Pharmacognosy Magazine
Correspondence: An-bin Zhao
Department of Internal Medicine, Xinzheng Chinese Medical Hospital, Zhengzhou, People's Republic of China.
Email: tchenxiaoyin@jnu.edu.cn
Correspondence: Bin YU
Department of Traditional Chinese Medicine, Medical College, Jinan University, Guangzhou, People's Republic of China.
Email: tchenxiaoyin@jnu.edu.cn
Correspondence: Xiao-Yin Chen
Department of Traditional Chinese Medicine, Medical College, Jinan University, Guangzhou, People's Republic of China.
Email: tchenxiaoyin@jnu.edu.cn
Copyright: © 2011 Manuscript Technomedia. This is an open access article.
- Published:
- May 9, 2011
- Received:
- Sep 16, 2010
How to cite
Zhao, A. B., YU, B., WU, X. L., Cao, K. J., LI, E. Q., LI, Q. M., & Chen, X. Y. (2011). Protective effects on myelosuppression mice treated by three different classic Chinese medicine formulae. Pharmacognosy Magazine, 7(26), 133–140. https://doi.org/10.4103/0973-1296.80671
Abstract
Background: In order to observe the protective therapeutic action and mechanism of Liuwei Dihuang Decoction, Buzhong Yiqi Decoction, and Compound Danshen Decoction on Myelosuppression induced by cyclophosphamide. Materials and Methods: The mice model was established by intraperitoneal injected with 100 mg/kg cyclophosphamide by human and mice dose conversion on the 9th, 11th, 13th days during the experiment. Flow cytometry (FCM) was used for detecting the number of cells and investigating bone marrow cell cycles. Spleen was taken out and the mRNA expression level of thrombopoietin (TPO) and c-Mpl were detected by Q-PCR, and c-Mpl in spleen in order to discuss the mechanism of myelosuppression and the protective effects of traditional Chinese medicine. Results: Both Liuwei Dihuang Decoction Group and Buzhong Yiqi Decoction Group can accelerate bone marrow hematopoietic stem progenitor cells (HSPCs) in marrow-suppressed mice and enhance cell proliferation by promoting cell cycles from G0/G1 phase to access into S, G2/M phase. And at the same time these Chinese decoctions can increase the mRNA expression level of TPO and c-Mpl in spleen. Conclusion: Researched showed that Chinese formula take effect by affecting these genes on myelosuppressed mice.
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Article metadata
| Title | Protective effects on myelosuppression mice treated by three different classic Chinese medicine formulae |
|---|---|
| Authors | An-bin Zhao; Bin YU; Xian-Lin WU; Ke-Jian Cao; En-Qing LI; Qing-Mei LI; Xiao-Yin Chen |
| Affiliations | Department of Internal Medicine, Xinzheng Chinese Medical Hospital, Zhengzhou, People's Republic of China.; Department of Traditional Chinese Medicine, Medical College, Jinan University, Guangzhou, People's Republic of China.; Department of Traditional Chinese Medicine, School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.; Department of Laboratory, Guangzhou Red Cross Hospital, Guangzhou, People's Republic of, China. |
| Corresponding author | tchenxiaoyin@jnu.edu.cn |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 7, Issue 26 (2011) |
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