Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 9 | Issue 34 | 2013 | pp. 149–154Open access
Nimodipine rescues N-methyl-N-nitrosourea-induced retinal degeneration in rats
- 2,4,
- 3,
- 4,
- 2*,
- 1 Department of Histology and Embryology, College of Basic Medical Science, China Medical University, China.
- 2 Department of Physiology, Experimental Teaching Center of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, China.
- 3 Department of Pharmacology, HE’s University, China.
- 4 Department of Basic Pharmacology, Liaoning University of Traditional Chinese Medicine, Liaoning Shenyang, P. R, China.
Published in Pharmacognosy Magazine
Correspondence: Gui-yuan Sun
Department of Physiology, Experimental Teaching Center of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, China.
Email: sunguiyuan@163.com
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 30, 2013
- Received:
- Feb 14, 2012
How to cite
Wang, D., Li, Y., Wang, Z., Sun, G. Y., & Zhang, Q. H. (2013). Nimodipine rescues N-methyl-N-nitrosourea-induced retinal degeneration in rats. Pharmacognosy Magazine, 9(34), 149–154. https://doi.org/10.4103/0973-1296.111276
Abstract
Background: That nimodipine (NMD) is potentially useful for ophthalmic treatment. However, the effect of NMD is unknown on retinal degenerative diseases. Objective: The purpose of the present study was to investigate the effect of NMD on N-methyl-N-nitrosourea (MNU)-induced retinal degeneration (RD) and elucidate its possible mechanisms. Materials and Methods: Morphological observation of NMD on MNU-induced RD was evaluated by light microscopy and electron microscopy. Nonenzymatic antioxidant glutathione (GSH) was measured by a colorimetric method. Transforming growth factor-beta (TGF-b) was measured by enzyme-linked immunosorbent assay (ELISA). Telomerase was detected by reverse transcriptase polymerase chain reaction (RT-PCR). Results: The significantly protective effect of NMD on MNU-induced RD was demonstrated morphologically. NMD increased the content of GSH and decreased the level of TGF-b in rat retina. RT-PCR analysis demonstrated that NMD treatment significantly decreased mRNA level of telomerase. Conclusion: These data suggest that NMD inhibit MNU-induced RD in rats. The expressions of TGF-b, telomerase and GSH contents might partially contribute to its protective effects on MNU-induced RD.
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Article metadata
| Title | Nimodipine rescues N-methyl-N-nitrosourea-induced retinal degeneration in rats |
|---|---|
| Authors | Dan Wang; Yan Li; Zhuo Wang; Gui-yuan Sun; Qiu-hua Zhang |
| Affiliations | Department of Histology and Embryology, College of Basic Medical Science, China Medical University, China.; Department of Physiology, Experimental Teaching Center of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, China.; Department of Pharmacology, HE’s University, China.; Department of Basic Pharmacology, Liaoning University of Traditional Chinese Medicine, Liaoning Shenyang, P. R, China. |
| Corresponding author | sunguiyuan@163.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 9, Issue 34 (2013) |
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