Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Natural ProductsVol. 36 | Issue 1 | 2022 | pp. 52–57Open access
Cassia occidentalis Potentiates wound Healing Process in Type-2 Diabetic Rats
- 1,2*,
- 1,
- 3,
- 4
- 1 Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, Madhya Pradesh, INDIA.
- 2 Department of Pharmacy, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh, INDIA.
- 3 Department of Pharmacognosy, Department of Pharmaceutical sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, INDIA.
- 4 Department of General Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, INDIA.
Published in Indian Journal of Natural Products
Correspondence: Rajesh Singh Pawar
Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, Madhya Pradesh, INDIA.; Department of Pharmacy, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh, INDIA.
Email: dr_pawar14@rediffmail.com
Copyright: © 2022 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2022
How to cite
Pawar, R. S., Mandloi, A. S., Patil, U. K., & Kumar, S. (2022). Cassia occidentalis Potentiates wound Healing Process in Type-2 Diabetic Rats. Indian Journal of Natural Products, 36(1), 52–57. https://doi.org/10.5530/ijnp.2022.1.8
Abstract
Introduction: This work is focus on a cost-effective herbal hydrogel formulation comprising of extract, from the leaves of Cassia occidentalis L. (Caesalpiniaceae). The formulation is highly effective for delayed wound healing due to diabetes.
Background: Cassia occidentalis (CO) is extensively used in folklore medicine system. It is a common weed scattered from foothills of Himalayas to West Bengal, South India, Burma and Srilanka.
Objectives: The study aimed to explore the role of Cassia occidentalis (leaf) for wound healing potential in diabetic rats using the excision wound model. Materials and Methods: The characterization of the phytoconstituents and bioavailability profiles of methanolic extract of CO (MCO) were investigated using High-Performance Liquid Chromatography-Photodiode Array Detector analysis. Insulin resistance was induced in rats by feeding them a diet rich in fructose and hyperglycemia was induced by injecting streptozotocin (STZ) at a dose of 40 mg/kg body weight (bw), intraperitoneally (ip). After confirmation of diabetes fasting blood glucose level, the wound was induced. Excision wound healing activity was examined on Wistar rats.
Results: The hydrogel of MCO (5 and 10%) reduced significantly wound size. Significant mean epithelialization period, higher hydroxyproline content and tensile strength were revealed at the concentrations of MCO hydrogel of 5 and 10% compared to the diabetic wound control group.
Conclusion: These results provide promising baseline information for the wound healing potential of MCO in type-2 diabetes treatment.
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Article metadata
| Title | Cassia occidentalis Potentiates wound Healing Process in Type-2 Diabetic Rats |
|---|---|
| Authors | Rajesh Singh Pawar; Avinash Singh Mandloi; Umesh Kumar Patil; Shweta Kumar |
| Affiliations | Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, Madhya Pradesh, INDIA.; Department of Pharmacy, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh, INDIA.; Department of Pharmacognosy, Department of Pharmaceutical sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, INDIA.; Department of General Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, INDIA. |
| Corresponding author | dr_pawar14@rediffmail.com |
| Journal | Indian Journal of Natural Products |
| Volume / Issue | Vol. 36, Issue 1 (2022) |
Also in this issue
- Message of Editor-in-Chiefpp. 1–1
- Repellent Activity of Plant Extracts, Essential Oils and their Combinations against Different Mosquito Species: A Reviewpp. 2–16
- High Performance Liquid Chromatography Standardisation of the Hydroalcoholic Extract of Phaseolus radiatus Beans Based on Vitexin Contentpp. 17–23
- High Performance Thin Layer Chromatographic Standardization and Quantification of Marker Compounds in an Ayurvedic Polyherbal Formulation Padmakadi Churnapp. 24–27
- Chromatographic Studies on Extracts of Ganoderma lucidumpp. 28–38
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