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Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 51 | Issue 3 | 2017 | pp. 480–489Open access
In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline
- 1*,
- 2,
- 3
- 1 Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
- 2 Departmentof Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
- 3 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Orissa, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: SahooJyotirmaya SahooJyotirmaya
Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
Email: jjyotisahoo@rediffmail.com
Copyright: © 2017 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 22, 2017
- Received:
- Dec 7, 2016
- Accepted:
- Feb 15, 2017
How to cite
SahooJyotirmaya, S., SarangiPriyambadaKshirodaNandini, S., & PaidesettySudhirKumar, P. (2017). In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline. Indian Journal of Pharmaceutical Education and Research, 51(3), 480–489. https://doi.org/10.5530/ijper.51.3.76
Abstract
Introduction: Novel Cu(II), Co(II) and Ni(II) complexes of 8-hydroxyquinolineazo analogues are synthesized from 5-((3-nitrophenyl)diazenyl) quinolin-8-ol (4a) and 5-((4-bromo-3- methylphenyl) diazenyl) quinolin-8-ol (4b). Methods: The structural environment and elemental composition of the synthesized metal complexes are confirmed by FT/IR, 1H NMR and CHNS/O elemental analyzer. The λmax and molecular mass are determined with the help of UV-visible and LC-MS spectrometer. Results: The magnetic susceptibility study suggested that the synthesized complexes are proposed with tetrahedral geometry. Among the six complexes, the bis bis 8, 8′ [5-((3-nitrophenyl) diazenyl) quinolinium] copper (4aLig2Cu) and bis 8, 8′ [5-((4-bromo-3-methylphenyl) diazenyl) quinolinium] copper (4bLig2Cu) showed significant antimicrobial activity. Conclusion: It was found that the metal complexes showed enhanced antimicrobial activity in comparison to their corresponding ligands.
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Article metadata
| Title | In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline |
|---|---|
| Authors | SahooJyotirmaya SahooJyotirmaya; SarangiPriyambadaKshirodaNandini SarangiPriyambadaKshirodaNandini; PaidesettySudhirKumar PaidesettySudhirKumar |
| Affiliations | Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.; Departmentof Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.; Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Orissa, INDIA. |
| Corresponding author | jjyotisahoo@rediffmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 51, Issue 3 (2017) |
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