Cobalt and Iron-based Heteroleptic Complexes of Imidazole: Synthesis, Antibacterial and Hemolytic Potential

Fouzia, Kiran; Akhtar, Muhammad Nadeem; Ali, Arfan; Taj, Muhammad Babar; Shahid, M.; Khan, Amin; Imran, Muhammad; Shahid, Muhammad

doi:10.5530/ijper.56.3s.161

Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 56 | Issue 3s | 2024 | pp. S515–S521Open access

Cobalt and Iron-based Heteroleptic Complexes of Imidazole: Synthesis, Antibacterial and Hemolytic Potential

¹,
^1,2^*,
³,
⁴,
⁵,
⁶,
²,
⁷

¹ Department of Chemistry, University of Agriculture, Faisalabad, PAKISTAN.
² Division of Inorganic Chemistry, Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, PAKISTAN.
³ Department of Pharmacology, The Islamia University of Bahawalpur, Bahawalpur, PAKISTAN.
⁴ Department of Chemistry, University of Agriculture, Faisalabad, PAKISTAN.
⁵ Functional Inorganic Materials Lab (FIML), Department of Chemistry, Aligarh Muslim University, Aligarh, INDIA.
⁶ Deparment of Chemistry, University of Science and Technology, Bannu, PAKISTAN.
⁷ Department of Biochemistry, University of Agriculture, Faisalabad, PAKISTAN.

Correspondence: Muhammad Nadeem Akhtar
Department of Chemistry, University of Agriculture, Faisalabad, PAKISTAN.; Division of Inorganic Chemistry, Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, PAKISTAN.
Email: nadeemchem@yahoo.com

Published:: Jan 1, 2024
Received:: Mar 16, 2021
Accepted:: May 4, 2022
DOI:: 10.5530/ijper.56.3s.161

How to cite

Fouzia, K., Akhtar, M. N., Ali, A., Taj, M. B., Shahid, M., Khan, A., Imran, M., & Shahid, M. (2024). Cobalt and Iron-based Heteroleptic Complexes of Imidazole: Synthesis, Antibacterial and Hemolytic Potential. Indian Journal of Pharmaceutical Education and Research, 56(3s), S515–S521. https://doi.org/10.5530/ijper.56.3s.161

Abstract

Transition metal complexes can deliver exciting properties in the development of metalbased drug system. The aim of current study is to synthesis of metal complexes and to evaluate their biological properties such as antibacterial and hemolytic activity to know their biological importance. Five cobalt and iron-based complexes (1-5), [CoII(imiH)(benz) (N₃)] (1) [FeII(imiH)(piv)(N₃)] (2), [FeII(imiH)(benz)(N₃)] (3), [FeII(imiH)(N₃)₂] (4), [FeII(imiH) (piv)₂] (5), (where imiH = imidazole, piv = pivalic acid, N^3- = azide, benz = benzoic acid) were produced by of the reacting of respective metal salts with selective ligands. These complexes were characterized through FTIR and elemental analyses. Compounds (1-5) were tested for their antibacterial biofilm inhibition and hemolytic studies. Complexes of 3 (85.42%) and 2 (69.58%) have promising inhibition for S. aureus whereas 5 (70.48%) and 2 (62.94%) also exhibit significant inhibition against E. coli. The hemolytic study of these metal complexes indicates the cytotoxicity against bovine erythrocytes. The current study will be useful for the development metallodrugs in future.

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Article metadata

Title	Cobalt and Iron-based Heteroleptic Complexes of Imidazole: Synthesis, Antibacterial and Hemolytic Potential
Authors	Kiran Fouzia; Muhammad Nadeem Akhtar; Arfan Ali; Muhammad Babar Taj; M. Shahid; Amin Khan; Muhammad Imran; Muhammad Shahid
Affiliations	Department of Chemistry, University of Agriculture, Faisalabad, PAKISTAN.; Division of Inorganic Chemistry, Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, PAKISTAN.; Department of Pharmacology, The Islamia University of Bahawalpur, Bahawalpur, PAKISTAN.; Department of Chemistry, University of Agriculture, Faisalabad, PAKISTAN.; Functional Inorganic Materials Lab (FIML), Department of Chemistry, Aligarh Muslim University, Aligarh, INDIA.; Deparment of Chemistry, University of Science and Technology, Bannu, PAKISTAN.; Department of Biochemistry, University of Agriculture, Faisalabad, PAKISTAN.
Corresponding author	nadeemchem@yahoo.com
Journal	Indian Journal of Pharmaceutical Education and Research
Volume / Issue	Vol. 56, Issue 3s (2024)