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Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 59 | Issue 3s | 2025 | pp. s1134–s1140Open access
Quantification of Miconazole Nitrate and Eugenol in Formulated Emulgel by Planar Chromatography along its Stability Studies
- 1*,
- 1*,
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- 2*,
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- 1 Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University), Piparia, Waghodia, Vadodara, Gujarat, INDIA .
- 2 Department of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, INDIA .
- 3 Department of Pharmaceutical Chemistry, P. R. Pote Patil College of Pharmacy, Kathora Naka, Amravati, Maharashtra, INDIA .
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Aarti Sachin Zanwar
Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University), Piparia, Waghodia, Vadodara, Gujarat, INDIA .
Email: aarti.zanwar@gmail.com
Copyright: © 2025 Manuscript Technomedia. This is an open access article.
- Published:
- Jul 11, 2025
- Received:
- Jan 28, 2025
- Accepted:
- May 13, 2025
How to cite
Zanwar, A. S., Sen, D. B., Vyas, P. H., Burle, S. S., Ruikar, D. B., & Sen, A. K. (2025). Quantification of Miconazole Nitrate and Eugenol in Formulated Emulgel by Planar Chromatography along its Stability Studies. Indian Journal of Pharmaceutical Education and Research, 59(3s), s1134–s1140. https://doi.org/10.5530/ijper.20255177
Abstract
Introduction:
Fungal infections are rapidly increasing and combination therapy using Miconazole Nitrate (MCZ) and Eugenol (EGN), may offer a promising approach for developing new antifungal medications.
Objectives:
The purpose of the demonstrated work was to develop and validate a stability-indicating HPTLC method for concurrent measurement of MCZ and EGN in formulated emulgel.
Materials and Methods:
The separation technique of the HPTLC method was aided by pre-coated silica gel 60F254 on aluminium and toluene: ethyl acetate: methyl alcohol (18:1:1 v/v/v) as mobile phase. The quantification of MCZ and EGN in formulated emulgels along with their stability studies was conducted.
Results:
The optimised conditions were used to develop the spotted drugs and showed a linear response from 100-600 ng/band (r2=0.9995) for MCZ at Rf value of 0.33 and 53-318 ng/band (r2=0.9996) for EGN at Rf value of 0.70.
Conclusion:
The proposed validated work is suitable for the quantification of the above-cited drugs under various stress conditions and quality control purpose.
Keywords
Subject
Article metadata
| Title | Quantification of Miconazole Nitrate and Eugenol in Formulated Emulgel by Planar Chromatography along its Stability Studies |
|---|---|
| Authors | Aarti Sachin Zanwar; Dhanya B Sen; Pruthvi Hiteshkumar Vyas; Sushil Sureshrao Burle; Dipti Bipinchandra Ruikar; Ashim Kumar Sen |
| Affiliations | Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University), Piparia, Waghodia, Vadodara, Gujarat, INDIA .; Department of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, INDIA .; Department of Pharmaceutical Chemistry, P. R. Pote Patil College of Pharmacy, Kathora Naka, Amravati, Maharashtra, INDIA . |
| Corresponding author | aarti.zanwar@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 59, Issue 3s (2025) |
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