Design, Fabrication and Characterization of Transdermal Patches Using Different Natural Polymers Containing Caffeine and Ibuprofen for Long-Term Management of Migraine

Background

The study explores transdermal drug delivery as a solution to traditional oral and parenteral administration challenges, highlighting improvements in efficiency and scope with micro needle technology.

Objectives

The primary objective of this study was to fabricate a natural gum-grafted matrix transdermal patch for prolonged migraine treatment, emphasizing it’s in vitro characterization.

Materials and Methods

The materials utilized included active pharmaceutical ingredients (Ibuprofen, Caffeine), polymers (HPMC, Tamarind and Moringa), solvent (distilled water), permeation enhancer (Tween-80 5%w/w) and a backing layer. For the fabrication of the patches modified solvent evaporation method was employed.

Results and Discussion

The physical characteristics, including folding endurance and drug content, are within the official limit. The thermal analysis shows its excellent thermal stability. The in vitro drug release shows the maximum 98.3% drug release up to 24 hr, while the release kinetic shows its sustained behavior upon applying different kinetic models.

Conclusion

In conclusion, this innovative and economical transdermal approach holds promise for prolonged migraine management for up to 24 hr, offering a potential alternative to address challenges associated with traditional delivery methods used.