An In-depth Review of Exploring the Potential of Colloidosomes in Drug Delivery

Colloidosomes, pioneering microcapsules composed of coagulated colloidal particles assembled at the interface of emulsion droplets, have garnered significant attention due to their remarkable properties and potential applications in targeted and controlled drug delivery. Their unique core-shell architecture offers unparalleled advantages, including tunable permeability, mechanical strength and encapsulation capabilities for a wide range of therapeutic agents. These versatile carriers have demonstrated remarkable potential in delivering small molecules, biomacromolecules, genetic materials and even living cells, addressing challenges associated with conventional drug delivery systems. Colloidosomes can be fabricated through various techniques, encompassing emulsion-based, nature-of-colloids-based and emerging methods such as microfluidics and 3D printing. Comprehensive characterization, employing techniques like electron microscopy, spectroscopy and rheology, is crucial for understanding their structural, physical and functional properties. Remarkable advancements have been achieved in developing stimuli-responsive, targeted and multi-functional colloidosomes, enabling precise spatiotemporal control, selective accumulation and integrated functionalities for theranostic applications. Despite their immense potential, challenges remain in scaling up production, ensuring long-term stability, navigating regulatory landscapes and facilitating clinical translation. Addressing these obstacles through collaborative efforts, advanced characterization and the integration of emerging technologies is paramount for unlocking the full potential of colloidosomes in revolutionizing drug delivery strategies and realizing personalized medicine.