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Original ArticleJournal of Young PharmacistsVol. 10 | Issue 2 | 2018 | pp. 193–196Open access
Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia
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- 1 Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Pyatigorsk, RUSSIA.
Published in Journal of Young Pharmacists
Correspondence: Pozdnyakov DI
Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Pyatigorsk, RUSSIA.
Email: pozdniackow.dmitry@yandex.ru
Copyright: © 2018 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 4, 2018
- Received:
- Nov 18, 2017
- Accepted:
- Jan 8, 2018
How to cite
DI, P., AV, V., DS, Z., & AV, A. (2018). Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia. Journal of Young Pharmacists, 10(2), 193–196. https://doi.org/10.5530/jyp.2018.10.43
Abstract
Objective: To assess the effect of 4-hydroxy-3,5-di-tret-butyl cinnamic acid on the state of endothelial function under conditions of experimental cerebral ischemia. Materials and Methods: Antioxidant properties of 4-hydroxy-3,5-di-tret-butyl cinnamic acid and the effect of this compound on NO-synthase system activity and ADMA concentration were evaluated. Results: As a result, it has been found that the use of 4-hydroxy-3,5-di-tretbutyl cinnamic acid promotes reduction activity of catalase, glutathione peroxidase, superoxide dismutase and a decrease in the concentration of MDA and DC. In addition, the ability to modulate NO synthase system activity was established for this compound: an increase in eNOS activity by 114.2% (p <0.05), decrease activity of nNOS and iNOS by 60.6% (p <0.05) and 61.9% (p <0.05), respectively, decrease concentration of ADMA by 83.9% (p <0.05). Conclusion: The results of the conducted researches it is established that 4-hydroxy-3,5-di-tret-butyl cinnamic acid has antioxidant and NOS – regulating effect.
Keywords
Subject
Article metadata
| Title | Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia |
|---|---|
| Authors | Pozdnyakov DI; Voronkov AV; Zolotych DS; Arlt AV |
| Affiliations | Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Pyatigorsk, RUSSIA. |
| Corresponding author | pozdniackow.dmitry@yandex.ru |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 10, Issue 2 (2018) |
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