Open access · Peer reviewed · No APCs
Original ArtcileJournal of Young PharmacistsVol. 13 | Issue 1 | 2021 | pp. 68–71Open access
Evaluation of the Effects of Propolis and Xylitol Chewable Tablets on the Salivary Concentrations of Oral Micro-organisms in Orthodontic Patients: A Pilot Study
- 1,
- 2,
- 3,
- 3,
- 3,
- 3,
- 3,
- 3,
- 3,
- 3,
- 3,
- 3,
- 4,
- 3,
- 5,
- 6,
- 7,
- 8,
- 8*
- 1 Veterinary Medicine School, State University of Ceara, Fortaleza, CE, BRAZIL.
- 2 Health Multidisciplinary Residence Program, Public Health School from Ceara State, Fortaleza, CE, BRAZIL.
- 3 Pharmacy College, Catholic University Center of Quixadá, Quixadá, CE, BRAZIL.
- 4 Department of Health Sciences, Division of Microbiology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, SP, BRAZIL.
- 5 Dentistry College, Unichristus University Center, Fortaleza, CE, BRAZIL.
- 6 Pharmacy College, Unifanor University Center, Fortaleza, CE, BRAZIL.
- 7 Dentistry Faculty, Arthur Sá Earp Neto University Center, Petropolis, RJ, BRAZIL.
- 8 Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, CE, BRAZIL.
Published in Journal of Young Pharmacists
Correspondence: Edilson Martins Rodrigues Neto
Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, CE, BRAZIL.
Email: edilsonmrneto@hotmail.com
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 28, 2021
- Received:
- Dec 20, 2020
- Accepted:
- Jan 21, 2021
How to cite
Siqueira, É. C., Campos, F. M. T., Mendes, J. C., Lima, L. N. D., Araújo, R. S., Gomes, N. K. S., Lima, L. R. D. S., Nogueira, R. F., Rocha, M. C. D. S., Barros, R. J. V., Bandeira, C. E. M., Sales, J. P. D., Fraga, E. G. D. S., Nogueira, L. D. S., Meneses, C. A. O., Albuquerque, R. L. D., Calcia, T. B. B., Lobo, P. L. D., & Neto, E. M. R. (2021). Evaluation of the Effects of Propolis and Xylitol Chewable Tablets on the Salivary Concentrations of Oral Micro-organisms in Orthodontic Patients: A Pilot Study. Journal of Young Pharmacists, 13(1), 68–71. https://doi.org/10.5530/jyp.2021.13.15
Abstract
Objectives: This study sought to evaluate the effectiveness of red propolis and xylitol chewable tablets in reducing concentrations of micro-organisms such as Streptococcus mutans (SM) and gram-negative bacteria (GNB). Methods: A total of 12 volunteers of both sexes presenting no caries (ICDAS II 0), users of fixed orthodontic appliances and with visible plaque index were randomly assigned to one of two groups. Was to determine the variations in the concentrations of SM and GNB in the saliva before and after the administration of the chewable tablets. The appearance of adverse reactions and side effects was analyzed. The Mann-Whitney (parametric) test was used for pairwise comparisons of means. The Wilxocon test was also used. Results: The study revealed that the propolis and xylitol chewable tablets had antimicrobial activity, reducing the concentration of GNB by -1.39 log10 CFU/mL (p = 0.036) and compared to placebo (p = 0.004698). There was a significant reduction of SM of -0.22 log10 CFU/mL (p = 0.031) and compared to placebo (p = 0.002165). Conclusion: Thus, in addition to the good safety profile, with a low rate of adverse effects, red propolis and xylitol tablets proved to be an effective potential low-cost alternative to combat dental caries and other periodontal diseases.
Keywords
Subject
Article metadata
| Title | Evaluation of the Effects of Propolis and Xylitol Chewable Tablets on the Salivary Concentrations of Oral Micro-organisms in Orthodontic Patients: A Pilot Study |
|---|---|
| Authors | Érica Cardoso Siqueira; Fernanda Maria Teófilo Campos; Jerlyson Coelho Mendes; Larisse Nogueira De Lima; Ruth Sousa Araújo; Nara Karoliny Sousa Gomes; Luiza Rayanne da Silva Lima; Rodrigo Freires Nogueira; Maria Célia da Silva Rocha; Raimundo Juarez Viana Barros; Carlos Eduardo Marques Bandeira; Jair Paulino de Sales; Edmir Geraldo de Siqueira Fraga; Lara da Silva Nogueira; Carlos Augusto Oliveira Meneses; Roberto Lima de Albuquerque; Thayanne Brasil Barbosa Calcia; Patricia Leal Dantas Lobo; Edilson Martins Rodrigues Neto |
| Affiliations | Veterinary Medicine School, State University of Ceara, Fortaleza, CE, BRAZIL.; Health Multidisciplinary Residence Program, Public Health School from Ceara State, Fortaleza, CE, BRAZIL.; Pharmacy College, Catholic University Center of Quixadá, Quixadá, CE, BRAZIL.; Department of Health Sciences, Division of Microbiology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, SP, BRAZIL.; Dentistry College, Unichristus University Center, Fortaleza, CE, BRAZIL.; Pharmacy College, Unifanor University Center, Fortaleza, CE, BRAZIL.; Dentistry Faculty, Arthur Sá Earp Neto University Center, Petropolis, RJ, BRAZIL.; Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, CE, BRAZIL. |
| Corresponding author | edilsonmrneto@hotmail.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 13, Issue 1 (2021) |
Also in this issue
- Cellulose Bio–ink on 3D Printing Applicationspp. 1–6
- A Review on Analytical Methods for Antiviral Phytoconstituentspp. 7–13
- Oral and Maxillofacial Complications due to the use of Hyaluronic Acid as an Alternative for Facial Implantspp. 14–18
- The Effect of Glucosamine With or Without Chondroitin Sulphate on Glucose Monitoring Parameters in Humans – A Systematic Reviewpp. 19–24
- Adverse Reactions of Proton Pump Inhibitors: A Literature Reviewpp. 25–27
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026