Original ArtcileJournal of Young PharmacistsVol. 15 | Issue 1 | 2022 | pp. 182–188Open access
Evaluation of Chewing Gums Containing Natural Products on Salivary Concentrations of Streptococcus mutans in Children
- 1,
- 2*,
- 2,
- 3,
- 2,
- 4,
- 5,
- 2,
- 6
- 1 Department of Health Sciences, Division of Microbiology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, BRAZIL.
- 2 Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceará, Fortaleza, CE, BRAZIL.
- 3 Catholic University, Center of Quixadá, Quixadá, CE, BRAZIL.
- 4 Paulo Picanço Dental School, CE, BRAZIL.
- 5 Department of Pharmacy, Faculty of Vale Jaguaribe, Aracati, CE, BRAZIL.
- 6 Department of Paediatrics, Santa Casa de São Paulo School of Medical Sciences, São Paulo, BRAZIL.
Published in Journal of Young Pharmacists
Correspondence: Edilson Martins Rodrigues Neto
Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceará, Fortaleza, CE, BRAZIL.
Email: edilsonmrneto@hotmail.com
Copyright: © 2022 Manuscript Technomedia. This is an open access article.
- Published:
- Dec 28, 2022
- Received:
- Oct 16, 2022
- Accepted:
- Dec 6, 2022
- DOI:
- 10.5530/097515050561
How to cite
Fraga, E. G. D. S., Neto, E. M. R., Campos, F. M. T., Cavalcante, M. P. D. S., Amorim, F. A., Martins, L. F. B., Sousa, A. K. M., Fiallos, A. C. D. M., & Mimica, M. J. (2022). Evaluation of Chewing Gums Containing Natural Products on Salivary Concentrations of Streptococcus mutans in Children. Journal of Young Pharmacists, 15(1), 182–188. https://doi.org/10.5530/097515050561
Abstract
Background: Streptococcus mutans (S. mutans) are present in the bacterial biofilm involved in the onset and progression of childhood caries, favoring acid production and dental demineralization. Sugar consumption favors the high incidence of caries in childhood, from 5 to 12 years old. A chewable lozenge incorporated with natural antimicrobial agents of recognized potency, such as red propolis and xylitol, would be an adjuvant to control caries. Materials and Methods: This is a randomized, placebo-controlled, cross-sectional clinical trial. 40 participants were divided into four groups: Placebo (group I), Red Propolis 2.5% (group II); Red propolis 6.4% (group III) and Xylitol 15% (group IV). They had saliva collected at different times of the trial for analysis of antimicrobial action. The study was registered with REBEC. Results: In the group I there were variations before and after the administration of the tablets, but no statistical significance, in relation to the group II it was found a significant reduction in the salivary concentration of S. mutans in all salivary dilutions (34,25% - 63,65%), fact observed with the group III (38,42% - 45,02%) and group IV (50,72% - 42,92%). Conclusion: With encouraging results, further studies are needed for a longitudinal follow-up, being a low-cost alternative with anticariogenic potential.
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Article metadata
| Title | Evaluation of Chewing Gums Containing Natural Products on Salivary Concentrations of Streptococcus mutans in Children |
|---|---|
| Authors | Edmir Geraldo de Siqueira Fraga; Edilson Martins Rodrigues Neto; Fernanda Maria Teófilo Campos; Manoel Patrick da Silva Cavalcante; Frederico Augusto Amorim; Luiz Filipe Barbosa Martins; Antônia Kelly Martins Sousa; Ana Cristina de Mello Fiallos; Marcelo Jenné Mimica |
| Affiliations | Department of Health Sciences, Division of Microbiology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, BRAZIL.; Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceará, Fortaleza, CE, BRAZIL.; Catholic University, Center of Quixadá, Quixadá, CE, BRAZIL.; Paulo Picanço Dental School, CE, BRAZIL.; Department of Pharmacy, Faculty of Vale Jaguaribe, Aracati, CE, BRAZIL.; Department of Paediatrics, Santa Casa de São Paulo School of Medical Sciences, São Paulo, BRAZIL. |
| Corresponding author | edilsonmrneto@hotmail.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 15, Issue 1 (2022) |
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