Postulation of Therapeutic Potential of Meha Mudgara Rasa in Management of Diabetic Neuropathy through High-Performance Thin Layer Chromatography (HPTLC) Analysis

Background: Meha Mudgara Rasa (MMR) is a classical Ayurvedic herbo-mineral formulation that is traditionally used in the management of diabetes. Despite its long-standing therapeutic use, scientific validation of its pharmacognostic profile and its antidiabetic efficacy is limited. This study aimed to evaluate the phytochemical composition and antidiabetic potential of MMR using modern analytical techniques. Materials and Methods: Raw materials for Meha Mudgara Rasa were verified as per Ayurvedic Pharmacopoeia. Kanta Loha Bhasma was subjected to Amruteekaran and Puta. The drug was formulated through classical process with trituration, Bhavana by Triphala decoction, and tablet making. Physicochemical values (e.g., hardness, disintegration, ash values) were evaluated. Methanolic extracts were analyzed using High-Performance Thin-Layer Chromatography (HPTLC) for phytochemical fingerprints. Results: The tablets were black with typical taste and smell. Physicochemical evaluation validated conformance with pharmacopoeial requirements. HPTLC showed clear chromatographic fingerprints at 254 nm and 366 nm, and identification of bioactive compounds using Rf values and comparison to PubChem. Conclusion: This study supports the traditional use of Meha Mudgara Rasa in the management of diabetes. Its therapeutic effects may be attributed to the synergistic action of its phytochemical constituents. Further pharmacological and clinical studies are warranted to elucidate its mechanisms and confirm its clinical applicability.