Synthesis and Evaluation of Novel Azo-Schiff’s Bases with Antimicrobial Potentials

Background

Antimicrobial agents occupy a significant importance today due to the increasing challenge posed by microbial resistance to existing drugs. Azo dyes, time tested compounds, known for their antimicrobial efficacy, have demonstrated potent activity against both bacteria and fungi. However, the emergence of resistance among microorganisms to these compounds necessities the development of new azo dye derivatives with better activity profile.

Materials and Methods

In the present study, a series of azo dye compounds were synthesized from coupling diazotized Schiff bases with β-naphthol. The synthesized compounds were characterized using various spectroscopic techniques The in silico studies were conducted to know the potency of these compounds on selected bacterial proteins 5 XDT and 1Q8I from pdb belongs to selected gram+ve and gram-ve bacteria, and the results have shown significant potency towards their ability to inhibit the bacteria.

Results

Based on the in silico studies, the compounds were subjected for in vitro antimicrobial analysis and the results revealed that the synthesized compounds exhibited prominent antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans.

Discussion

These results highlighted the antimicrobial potential of the compounds as promising lead molecules for the development of antimicrobial agents. Furthermore, these findings suggest the possible application in both healthcare and industrial settings as antimicrobial agents.

Conclusion

These findings indicate that the synthesized Schiff’s Bases-Azo dyes are promising antimicrobial compounds for antimicrobial and industrial applications.