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Research PaperJournal of Pharmacology and PharmacotherapeuticsVol. 1 | Issue 1 | 2010 | pp. 38–39Open access
Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models
- 1*,
- 2,
- 2,
- 2
- 1 Department of Pharmacology, TIFAC-CORE, J.S.S College of Pharmacy, Ootacamund, India.
- 2 Green Milk Concepts, Herbal Division of Apex Laboratories, Chennai – 600 038, India.
Published in Journal of Pharmacology and Pharmacotherapeutics
Correspondence: S. Parasuraman
Department of Pharmacology, TIFAC-CORE, J.S.S College of Pharmacy, Ootacamund, India.
Email: parasuphd@gmail.com
Copyright: © 2010 Manuscript Technomedia LLP. This is an open access article.
- Published:
- Jan 1, 2010
How to cite
Parasuraman, S., Kumar, E., Kumar, A., & Emerson, S. (2010). Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models. Journal of Pharmacology and Pharmacotherapeutics, 1(1), 38–39. https://doi.org/10.4103/0976-500X.64535
Abstract
Objective: To determine the in vitro free radical scavenging property and in vivo diuretic effect of TriglizeTM, a marketed polyherbal formulation in experimental models. Materials and Methods: The aqueous extract of polyherbal formulation (PHF) triglize was used for the experiment. The free radical scavenging property and antioxidant effect of PHF were studied by LPS-induced free radicals in rat macrophages cells and DPPH (2, 2-Diphenyl-1-Picrylhydrazyl) methods, respectively. The diuretic effect of a PHF was studied with Lipschitz model using male Wistar rats. Results: PHF signifi cantly inhibited lipopolysaccharide-induced free radicals in rat macrophages and it showed moderate antioxidant potential in DPPH model. Polyherbal formulation at 50, 200 and 400 mg/ kg signifi cantly increased potassium excretion in urine at 0-5 h and 5-24 h. The diuretic effect of PHF was as similar as furosemide. Conclusion: The PHF has signifi cant diuretic effect and free radical scavenging properties.
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Article metadata
| Title | Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models |
|---|---|
| Authors | S. Parasuraman; EP. Kumar; Anil Kumar; SF. Emerson |
| Affiliations | Department of Pharmacology, TIFAC-CORE, J.S.S College of Pharmacy, Ootacamund, India.; Green Milk Concepts, Herbal Division of Apex Laboratories, Chennai – 600 038, India. |
| Corresponding author | parasuphd@gmail.com |
| Journal | Journal of Pharmacology and Pharmacotherapeutics |
| Volume / Issue | Vol. 1, Issue 1 (2010) |
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