Open access · Peer reviewed · No APCs
Case ReportJournal of Pharmacology and PharmacotherapeuticsVol. 6 | Issue 3 | 2015 | pp. 179–181Open access
Life‑threatening bradyarrhythmia with oral phenytoin overdose
- 1,
- 1*,
- 1,
- 1
- 1 Subrahmanyam Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Published in Journal of Pharmacology and Pharmacotherapeutics
Correspondence: Mukta Wyawahare
Subrahmanyam Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Email: mukta.wyawahare@gmail.com
Copyright: © 2015 Manuscript Technomedia LLP. This is an open access article.
- Published:
- Jan 1, 2015
- Received:
- Sep 27, 2014
- Accepted:
- Dec 21, 2014
How to cite
Srinivasan, G., Wyawahare, M., Mathen, P. G., & K., D. (2015). Life‑threatening bradyarrhythmia with oral phenytoin overdose. Journal of Pharmacology and Pharmacotherapeutics, 6(3), 179–181. https://doi.org/10.4103/0976-500X.162017
Abstract
We report a case of a 41‑year‑old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a temporary transvenous pacer for her hemodynamic instability. This life‑threatening cardiotoxicity of phenytoin could have been due to its interaction with sulphonylurea. It is imperative to be aware of drug interactions, due to which, life‑threatening cardiovascular manifestations following phenytoin toxicity can occur.
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Article metadata
| Title | Life‑threatening bradyarrhythmia with oral phenytoin overdose |
|---|---|
| Authors | Giridharan Srinivasan; Mukta Wyawahare; Pratheesh George Mathen; Dharanipragada K. |
| Affiliations | Subrahmanyam Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. |
| Corresponding author | mukta.wyawahare@gmail.com |
| Journal | Journal of Pharmacology and Pharmacotherapeutics |
| Volume / Issue | Vol. 6, Issue 3 (2015) |
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