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Case ReportJournal of Pharmacology and PharmacotherapeuticsVol. 7 | Issue 1 | 2016 | pp. 41–3Open access
Pioglitazone-induced congestive heart failure and pulmonary edema in a patient with preserved ejection fraction
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- 1 Department of Medicine, Dr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India.
Published in Journal of Pharmacology and Pharmacotherapeutics
Correspondence: Sujeet Raina
Department of Medicine, Dr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India.
Email: sujeetrashmishera@yahoo.co.in
Copyright: © 2016 Manuscript Technomedia LLP. This is an open access article.
- Published:
- Jan 1, 2016
- Received:
- Dec 30, 2014
- Accepted:
- Aug 8, 2015
How to cite
Jearath, V., Vashisht, R., Rustagi, V., Raina, S., & Sharma, R. (2016). Pioglitazone-induced congestive heart failure and pulmonary edema in a patient with preserved ejection fraction. Journal of Pharmacology and Pharmacotherapeutics, 7(1), 41–3. https://doi.org/10.4103/0976-500X.179363
Abstract
Pioglitazone‑induced heart failure is known in patients with underlying heart disease, but is not well documented in patients with normal left ventricular function. Pioglitazone has been very popular as it is an insulin sensitizer and insulin resistance is prevalent among Indians. Fluid retention exacerbates pre‑existing heart failure or precipitates heart failure in a patient with underlying left ventricular dysfunction. However, pathogenesis of heart failure in a patient with normal left ventricular function is not known. Probably it is due to dose‑related effect on pulmonary endothelial permeability, rather than alterations in left ventricular mass or ejection fraction. We report a patient who developed congestive heart failure and pulmonary edema with normal left ventricular function within 1 year of starting pioglitazone therapy. We have to be careful in monitoring all possible side effects during followup when patients are on pioglitazone therapy.
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Subject
Article metadata
| Title | Pioglitazone-induced congestive heart failure and pulmonary edema in a patient with preserved ejection fraction |
|---|---|
| Authors | Vaneet Jearath; Rajan Vashisht; Vipul Rustagi; Sujeet Raina; Rajesh Sharma |
| Affiliations | Department of Medicine, Dr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India. |
| Corresponding author | sujeetrashmishera@yahoo.co.in |
| Journal | Journal of Pharmacology and Pharmacotherapeutics |
| Volume / Issue | Vol. 7, Issue 1 (2016) |
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