Open access · Peer reviewed · No APCs
Research ArticlePharmacognosy ResearchVol. 1 | Issue 3 | 2009 | pp. 130–135Open access
Cytotoxic acetogenins from Annona glabra cultivated in Egypt
- 1*,
- 2,
- 3,
- 4
- 1 Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
- 2 Pharmacognosy Department, National Research Centre Dokki, 12622 Giza, Egypt.
- 3 Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
- 4 Tanning and Protein Department, National Research Centre Dokki, Giza Egypt
Published in Pharmacognosy Research
Correspondence: Ahmed Abdel-lateff
Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
Email: aabelazim@yahoo.co.uk
Copyright: © 2009 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2009
- Received:
- Mar 10, 2009
- Accepted:
- Apr 9, 2009
How to cite
Abdel-lateff, A., El-Menshawi, B. S., Haggag, M. Y., & Nawwar, M. A. (2009). Cytotoxic acetogenins from Annona glabra cultivated in Egypt. Pharmacognosy Research, 1(3), 130–135.
Abstract
Bio-assay guided fraction of the methanolic extract of Annona glabra seeds (Annonaceae), cultivated in Egypt, revealed to the isolation of three bis-tetrahydrofuran acetogenins; squamocin-C (1), squamocin-D (2), and annonin I (3). Compounds 1 and 2 were obtained as stereoisomeric mixture. All isolates were assayed for their cytotoxicity twards brine shrimp and five in vitro cancer cell lines (A549, HT29, MCF 7, RPMI, and U251), and showed significant activity The structures of all compounds were determined by interpretation of their NMR and MS analyses.
Keywords
Subject
Article metadata
| Title | Cytotoxic acetogenins from Annona glabra cultivated in Egypt |
|---|---|
| Authors | Ahmed Abdel-lateff; Bassem S. El-Menshawi; Mohamed Y. Haggag; Mahmoud A. Nawwar |
| Affiliations | Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.; Pharmacognosy Department, National Research Centre Dokki, 12622 Giza, Egypt.; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Tanning and Protein Department, National Research Centre Dokki, Giza Egypt |
| Corresponding author | aabelazim@yahoo.co.uk |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 1, Issue 3 (2009) |
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