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Research ArticlePharmacognosy ResearchVol. 1 | Issue 6 | 2009 | pp. 387–391Open access
Antifungal activity of Tabernaemontana stapfiana Britten (Apocynaceae) organic extracts
- 1,
- 2,
- 3,
- 4,
- 5,
- 6*
- 1 Kenya National Public Health Laboratory Services, P.O. Box 20176, 00100 GPO, Nairobi, Kenya
- 2 Center for Microbiology, Research Kenya Medical Research Institute, P.O. Box 2632, 00202, Nairobi, Kenya
- 3 Department of Physical Science, Masinde Muliro University of Science and Technology, P.O. Box 190, 50100 Kakamega, Kenya
- 4 Chemistry Department
- 5 Department of Pharmacy and Complementary Medicine
- 6 Department of Plant and Microbial Sciences, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844, 00100 GPO, Nairobi, Kenya
Published in Pharmacognosy Research
Correspondence: P. Okemo
Department of Plant and Microbial Sciences, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844, 00100 GPO, Nairobi, Kenya
Email: okemo1952@yahoo.com
Copyright: © 2009 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2009
- Received:
- Sep 6, 2009
- Accepted:
- Oct 12, 2009
How to cite
Ruttoh, E., Bii, C., Tarus, P., Machocho, A., Karimi, L., & Okemo, P. (2009). Antifungal activity of Tabernaemontana stapfiana Britten (Apocynaceae) organic extracts. Pharmacognosy Research, 1(6), 387–391.
Abstract
The methanol and successive (hexane, dichlroromethane, ethyl acetate and methanol) extracts of leaves, fruits, root and stem barks of Tabernaemontana stapfiana Britten were investigated for antifungal activity against four fungi; Candida albicans, Cryptococcus neoformans, Microsporum gypseum and Trichophyton mentagrophytes. The extracts of the different plant parts showed varied activities against the tested fungi with the stem and root barks showing significant antifungal activities. The minimum inhibitory concentrations (MICs) of methanol and sequential extracts ranged between 31.25 and 8000 μg/ml while the minimum fungicidal concentrations (MFCs) ranged between 125 and 8000 μg/ml. Among the test microorganisms, Candida albicans was the most susceptible with the lowest MIC of 31.25 μg/ml followed by Cryptococcus neoformans with an MIC of 62.25 μg/ml. These results show that it is possible to find antifungal compounds in the extracts of T. stapfiana.
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Article metadata
| Title | Antifungal activity of Tabernaemontana stapfiana Britten (Apocynaceae) organic extracts |
|---|---|
| Authors | E.K. Ruttoh; C. Bii; P.K. Tarus; A. Machocho; L.K. Karimi; P. Okemo |
| Affiliations | Kenya National Public Health Laboratory Services, P.O. Box 20176, 00100 GPO, Nairobi, Kenya; Center for Microbiology, Research Kenya Medical Research Institute, P.O. Box 2632, 00202, Nairobi, Kenya; Department of Physical Science, Masinde Muliro University of Science and Technology, P.O. Box 190, 50100 Kakamega, Kenya; Chemistry Department; Department of Pharmacy and Complementary Medicine; Department of Plant and Microbial Sciences, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844, 00100 GPO, Nairobi, Kenya |
| Corresponding author | okemo1952@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 1, Issue 6 (2009) |
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