Open access · Peer reviewed · No APCs
Research ArticlePharmacognosy ResearchVol. 1 | Issue 6 | 2009 | pp. 392–395Open access
Antidiabetic Effect of Nauclea latifolia Leaf Ethanolic Extract in Streptozotocin-induced Diabetic Rats
- 1*,
- 2,
- 2,
- 1 Department of Biochemistry, University of Maiduguri, Maiduguri, Nigeria
- 2 Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
Published in Pharmacognosy Research
Correspondence: Gidado Abubakar
Department of Biochemistry, University of Maiduguri, Maiduguri, Nigeria
Email: abugidado@unimaid.edu.ng
Copyright: © 2009 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2009
- Received:
- Aug 23, 2009
- Accepted:
- Sep 18, 2009
How to cite
Abubakar, G., Danladi, A. A., Sunday, E. A., & Sani, I. (2009). Antidiabetic Effect of Nauclea latifolia Leaf Ethanolic Extract in Streptozotocin-induced Diabetic Rats. Pharmacognosy Research, 1(6), 392–395.
Abstract
The antidiabetic and possible toxicity of ethanolic extract of the leaf of Nauclea latifolia was studied in streptozotocin-induced diabetic rats. Doses of 100, 200 and 400mg/kg body weight were given orally to the STZ-induced diabetic rats daily for 45 days. All the doses showed significant hypoglycaemic effect. The effect is however not dose dependent. Indices of liver and kidney functions studied were not statistically affected by the extract administration. Ethanolic extract of the leaf of N. latifolia thus exhibited antidiabetic action in STZ-induced diabetic rats with minimal toxicity.
Keywords
Subject
Article metadata
| Title | Antidiabetic Effect of Nauclea latifolia Leaf Ethanolic Extract in Streptozotocin-induced Diabetic Rats |
|---|---|
| Authors | Gidado Abubakar; A. Ameh Danladi; E. Atawodi Sunday; Ibrahim Sani |
| Affiliations | Department of Biochemistry, University of Maiduguri, Maiduguri, Nigeria; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria |
| Corresponding author | abugidado@unimaid.edu.ng |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 1, Issue 6 (2009) |
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- Bioactivity-Directed Separation of an Anxiolytic Fraction from Aethusa cynapium L.pp. 336–341
- Chemical constituents and bioactivities of Malabaila suaveolenspp. 342–347
- A Comparative Study: Antimicrobial Activity of Methanol Extracts of Lantana camara Various Partspp. 348–351
- Antihyperglycemic and antioxidant activities of active fraction from the aqueous extract of Momordica cymbalaria fruits in Streptozotocin induced diabetic ratspp. 352–358
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