Modulation of Glucose Homeostasis and Behavioral Parameters by Passiflora edulis in a Rodent Model of Metabolic Syndrome Induced by High Fructose Intake

Background: Syndrome X (Metabolic syndrome), commonly associated with high-fructose dietary intake, is characterized by insulin resistance, hyperglycemia, and related neurobehavioral impairments. Passiflora edulis Extract (EPE), rich in bioactive compounds, is investigated for its potential therapeutic effects on fructose-induced MS. Materials and Methods: A total of five groups were formed using female Wistar rats (200-250 g, n=6). Group I served as the control group; Group II was exposed to 20% fructose to induce metabolic syndrome; Groups III to V received fructose along with EPE at 250, 500, and 1000 mg/kg doses, respectively, for a duration of 8 weeks. Biochemical parameters (blood glucose, insulin, HOMA-IR) and behavioral markers (locomotor activity, immobility time, fall time, paw withdrawal time) were recorded. Serum insulin was measured, and HOMA-IR was calculated. Results: Chronic fructose intake significantly increased blood glucose, insulin, and HOMA-IR values, indicating metabolic disruption. EPE administration significantly reduced these values in a dose-dependent manner, with the highest efficacy observed at 1000 mg/kg. EPE also improved behavioral outcomes: it increased fall time and locomotor activity, while decreasing immobility time and paw withdrawal time, demonstrating improvements in motor coordination, depressive-like behavior, and pain sensitivity. Effects were more pronounced at higher EPE doses. Conclusion: EPE significantly ameliorated both metabolic and neurobehavioral impairments induced by fructose in rats. Its dose-dependent efficacy suggests promising as a plant-based therapeutic for controlling metabolic syndrome and related behavioral dysfunctions.