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Original ArticlePharmacognosy ResearchVol. 2 | Issue 6 | 2010 | pp. 355–358Open access
Evaluation of in vitro cytotoxic effect of Trichosanthes dioica root
- 1*,
- 2
- 1 Bengal School of Technology (A College of Pharmacy), Sugandha, Hooghly 712102, West Bengal
- 2 Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim 737136, India.
Published in Pharmacognosy Research
Correspondence: Sanjib Bhattacharya
Bengal School of Technology (A College of Pharmacy), Sugandha, Hooghly 712102, West Bengal
Email: sakkwai@yahoo.com
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2010
- Received:
- Aug 14, 2010
- Accepted:
- Jan 12, 2011
How to cite
Bhattacharya, S., & Haldar, P. K. (2010). Evaluation of in vitro cytotoxic effect of Trichosanthes dioica root. Pharmacognosy Research, 2(6), 355–358. https://doi.org/10.4103/0974-8490.75454
Abstract
Background
Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English is a dioecious climber grown in India and used traditionally for various medicinal purposes.
Methods
Present study was aimed to evaluate in vitro cytotoxic effect of dichloromethane (DCTD), methanol (METD), and aqueous (AQTD) extracts of T. dioica root using Allium cepa root meristems by keeping them in different concentrations of each test extract under specific experimental conditions followed by determination of root growth inhibition (root length and number) and mitotic index.
Results
All the extracts significantly demonstrated concentration-dependent inhibition of root length and number and reduction in mitotic index, indicating antimitotic activity demonstrating cytotoxicity and genotoxicity. DCTD was found to be the most potent (EC50: 2.8 mg/ml), followed by METD and AQTD.
Conclusion
The present study therefore, establishes promising in vitro cytotoxic and genotoxic property of T. dioica root against the test system.
Keywords
Subject
Article metadata
| Title | Evaluation of in vitro cytotoxic effect of Trichosanthes dioica root |
|---|---|
| Authors | Sanjib Bhattacharya; Pallab K. Haldar |
| Affiliations | Bengal School of Technology (A College of Pharmacy), Sugandha, Hooghly 712102, West Bengal; Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim 737136, India. |
| Corresponding author | sakkwai@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 2, Issue 6 (2010) |
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