Open access · Peer reviewed · No APCs
EditorialPharmacognosy ResearchVol. 5 | Issue 1 | 2013 | pp. 17–21Open access
Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum
- 1*,
- 2,
- 1,
- 1,
- 1,
- 3
- 1 Department of Chemistry of Natural Compounds, National Research Centre, Dokki
- 2 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University
- 3 Department of Pharmacognosy, National Research Centre, Dokki, Cairo, Egypt
Published in Pharmacognosy Research
Correspondence: Mahmoud I. Nassar
Department of Chemistry of Natural Compounds, National Research Centre, Dokki
Email: mnassar_eg@yahoo.com
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2013
How to cite
Nassar, M. I., Aboutabl, E. S. A., Eskander, D. M., Grace, M. H., EL-Khrisy, E. D. A., & Sleem, A. A. (2013). Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum. Pharmacognosy Research, 5(1), 17–21. https://doi.org/10.4103/0974-8490.105643
Abstract
Background
Nothing is reported on Amphilophium paniculatum (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of Amphilophium paniculatum, grown in Egypt, in addition to pharmacological evaluation.
Materials and Methods
Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of A. paniculatum leaves.
Results
Identification of a new flavone glycoside, acacetin 8-C-b–D- glucopyranosy l-(1®2)–a-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD50) revealed that the different extracts were safe.
Keywords
Subject
Article metadata
| Title | Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum |
|---|---|
| Authors | Mahmoud I. Nassar; El-Sayed A. Aboutabl; Dina M. Eskander; Mary H. Grace; Ezzel-Din A. EL-Khrisy; Amany A. Sleem |
| Affiliations | Department of Chemistry of Natural Compounds, National Research Centre, Dokki; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University; Department of Pharmacognosy, National Research Centre, Dokki, Cairo, Egypt |
| Corresponding author | mnassar_eg@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 5, Issue 1 (2013) |
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